• English
    • français
  • English 
    • English
    • français
  • Login
View Item 
  •   Repository Home
  • Research Papers (RP)
  • RP-School of Health Sciences
  • RP-Department of Pharmacy & Complementary / Alternative Medicine
  • View Item
  •   Repository Home
  • Research Papers (RP)
  • RP-School of Health Sciences
  • RP-Department of Pharmacy & Complementary / Alternative Medicine
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Traditional Kenyan Herbal Medicine: Exploring Natural Products’ Therapeutics Against Schistosomiasis

Thumbnail
View/Open
Full text Article (418.8Kb)
Date
2022
Author
Ndegwa, Fidensio K
Kondam, Chaitanya
Aboagye, Samuel Y
Esan, Taiwo E
Waxali, Zohra Sattar
Miller, Margaret E
Gikonyo, Nicholas K
Mbugua, Paul K
Okemo, Paul O
Williams, David L
Hagen, Timothy J
Metadata
Show full item record
Abstract
Praziquantel (PZQ) remains the only drug of choice for the treatment of schistosomiasis, caused by parasitic flatworms. The widespread use of PZQ in schistosomiasis endemic areas for about four decades raises concerns about the emergence of resistance of Schistosoma spp. to PZQ under drug selection pressure. This reinforces the urgency in finding alternative therapeutic options that could replace or complement PZQ.We explored the potential of medicinal plants commonly used by indigenes in Kenya for the treatment of various ailments including malaria, pneumonia, and diarrhoea for their antischistosomal properties. Employing the Soxhlet extraction method with different solvents, seven medicinal plants Artemisia annua, Ajuga remota, Bredilia micranta, Cordia africana, Physalis peruviana, Prunus africana and Senna didymobotrya were extracted. Qualitative phytochemical screening was performed to determine the presence of various phytochemicals in the plant extracts. Extracts were tested against Schistosoma mansoni newly transformed schistosomula (NTS) and adult worms and the schistosomicidal activity was determined by using the adenosine triphosphate quantitation assay. Phytochemical analysis of the extracts showed different classes of compounds such as alkaloids, tannins, terpenes, etc., in plant extracts active against S. mansoni worms. Seven extracts out of 22 resulted in <20% viability against NTS in 24 h at 100 μg/ml. Five of the extracts with inhibitory activity against NTS showed >69.7% and ≥72.4% reduction in viability against adult worms after exposure for 24 and 48 h, respectively. This study provides encouraging preliminary evidence that extracts of Kenyan medicinal plants deserve further study as potential alternative therapeutics that may form the basis for the development of the new treatments for schistosomiasis
URI
http://ir-library.ku.ac.ke/handle/123456789/24906
Collections
  • RP-Department of Pharmacy & Complementary / Alternative Medicine [44]

Designed by Library ICT Team copyright © 2017 
Contact Us | Send Feedback

 

 

Browse

All of RepositoryCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

My Account

LoginRegister

Designed by Library ICT Team copyright © 2017 
Contact Us | Send Feedback