Traditional Kenyan Herbal Medicine: Exploring Natural Products’ Therapeutics Against Schistosomiasis

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dc.contributor.authorNdegwa, Fidensio K
dc.contributor.authorKondam, Chaitanya
dc.contributor.authorAboagye, Samuel Y
dc.contributor.authorEsan, Taiwo E
dc.contributor.authorWaxali, Zohra Sattar
dc.contributor.authorMiller, Margaret E
dc.contributor.authorGikonyo, Nicholas K
dc.contributor.authorMbugua, Paul K
dc.contributor.authorOkemo, Paul O
dc.contributor.authorWilliams, David L
dc.contributor.authorHagen, Timothy J
dc.date.accessioned2023-03-09T07:47:42Z
dc.date.available2023-03-09T07:47:42Z
dc.date.issued2022
dc.descriptionArticleen_US
dc.description.abstractPraziquantel (PZQ) remains the only drug of choice for the treatment of schistosomiasis, caused by parasitic flatworms. The widespread use of PZQ in schistosomiasis endemic areas for about four decades raises concerns about the emergence of resistance of Schistosoma spp. to PZQ under drug selection pressure. This reinforces the urgency in finding alternative therapeutic options that could replace or complement PZQ.We explored the potential of medicinal plants commonly used by indigenes in Kenya for the treatment of various ailments including malaria, pneumonia, and diarrhoea for their antischistosomal properties. Employing the Soxhlet extraction method with different solvents, seven medicinal plants Artemisia annua, Ajuga remota, Bredilia micranta, Cordia africana, Physalis peruviana, Prunus africana and Senna didymobotrya were extracted. Qualitative phytochemical screening was performed to determine the presence of various phytochemicals in the plant extracts. Extracts were tested against Schistosoma mansoni newly transformed schistosomula (NTS) and adult worms and the schistosomicidal activity was determined by using the adenosine triphosphate quantitation assay. Phytochemical analysis of the extracts showed different classes of compounds such as alkaloids, tannins, terpenes, etc., in plant extracts active against S. mansoni worms. Seven extracts out of 22 resulted in <20% viability against NTS in 24 h at 100 μg/ml. Five of the extracts with inhibitory activity against NTS showed >69.7% and ≥72.4% reduction in viability against adult worms after exposure for 24 and 48 h, respectively. This study provides encouraging preliminary evidence that extracts of Kenyan medicinal plants deserve further study as potential alternative therapeutics that may form the basis for the development of the new treatments for schistosomiasisen_US
dc.description.sponsorshipNational Institute of Allergy and Infectious Diseases (NIAID) Schistosomiasis Resource Center of the Biomedical Research Institute (Rockville, MD)en_US
dc.identifier.citationNdegwa, F. K., Kondam, C., Aboagye, S. Y., Esan, T. E., Waxali, Z. S., Miller, M. E., ... & Hagen, T. J. (2022). Traditional Kenyan herbal medicine: exploring natural products’ therapeutics against schistosomiasis. Journal of Helminthology, 96, e16.en_US
dc.identifier.otherhttps://doi.org/10.1017/S0022149X22000074
dc.identifier.urihttp://ir-library.ku.ac.ke/handle/123456789/24906
dc.language.isoenen_US
dc.publisherCambridge University pressen_US
dc.subjectTraditional medicineen_US
dc.subjectArtemisia annuaen_US
dc.subjectAjuga remotaen_US
dc.subjectBredilia micrantaen_US
dc.subjectCordia africanaen_US
dc.subjectPhysalis peruvianaen_US
dc.subjectPrunus africanaen_US
dc.subjectSenna didymobotryaen_US
dc.subjectschistosomiasisen_US
dc.titleTraditional Kenyan Herbal Medicine: Exploring Natural Products’ Therapeutics Against Schistosomiasisen_US
dc.typeArticleen_US
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