Hemostatic Activities of Methanol Leaf Extracts of Croton Megalocarpus Hutch and Lantana Camara Linn

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Date
2021Author
Muindi, Hezron
Kibiti, Cromwell
Ngugi, Mathew
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The effects of Croton megalocarpus Hutch and Lantana camara Linn plants leave
on blood coagulation has not been scientifically tested despite their common
use in bleeding control. The current study investigates the effects of the plants’
leaves extracts on mice plasma coagulation time. Leaves of C. megalocarpus (H.)
and L. camara (L.) were harvested, washed, air dried, crushed, extracted in
absolute methanol and concentrated to dry powders. Preliminary qualitative
phytochemical screen of both extracts was done. A total of 55 mice plasma
samples were mixed with solutions of leaves extracts of both plants, before
prothrombin time (PT) and activated partial thromboplastin time (aPTT) were
determined. Data was analyzed using one – way ANOVA. Phytochemical
screen on separate extracts of C. megalocarpus (H.) and L. camara (L.) revealed
the presence of tannins, phenols, cardiac glycosides, and terpenoids. Moreover,
C. megalocarpus (H.) extract contained steroids and flavonoids while that of L.
camara (L.) had saponins. Solutions of the various concentrations of methanol
leave extracts of C. megalocarpus (H.). L. camara (L.) and leaves blend extracts
from both plants reduced aPTT and PT significantly (p<0.05) when mixed with
normal mice plasma. Significant reduction of aPTT and PT of normal treated
plasma was associated with the activity of tannins, phenols, flavonoids and
saponins detected in the plant extracts.