Interpretational Tool for Fertility Hormonal Profile Established from a Healthy Adult Kenyan Population
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Date
2019
Authors
Waithaka, Stanley
Njagi, Eliud
Ngeranwa, Joseph
Journal Title
Journal ISSN
Volume Title
Publisher
Asian Journal of Medical Sciences
Abstract
Infertility is a reproductive disorder that affects both male and female and prevents them from bearing
desired child. Clinical laboratory plays a very important role in the process of investigating this disorder. A
prospective study carried out in clinical chemistry laboratory of Kenyatta National Hospital involving 491 healthy
individuals between 18-60 years. Reference ranges were constructed by using the parametric methods to estimate
2.5 and 97.5 percentiles of distribution as lower and upper reference limits. The fertility hormonal profile of the
adult healthy Kenyan population was carried out by investigating luitenizing (LH), follicle stimulating (FSH),
estradiol ii (EII), prolactin (PRL), progesterone PRG) and testosterone (TESTO) hormones; Four hundred and
ninety-one voluntarily study subjects comprising of 221 males and 270 females were recruited in the study. Sex
related reference values were established as follows:- TESTO [male (18-39 yrs [3.5-12.7 ng/mL], (40-50 yrs [2.5-
6.9 ng/mL), (51-61 yrs [1.8-5.6 ng/mL] female: follicular and luteal phases [0-2 ng/mL], ovulation phase [0.7-3.3
ng/mL] and Menopause [0-1.17 ng/ml, FSH [male;[0.7-7.5 (µU/mL] female: follicular phase [4-16µU/mL,
ovulation phase [5-20 µU/mL], luteal phases [2.5-7 µU/mL] and Menopause [0.11-1.89 µU/mL], LH [male;[ 0.5-5.7
µU/mL] female: follicular phase [0.7-8.6 µU/mL, ovulation phase [7-83µU/mL], luteal phase [0.4-6.8 µU/mL] and
Menopause [0.13-2.18µU/mL], EII [male;[ 0-25 pg/mL]female: follicular phase[0-200 pg/mL], ovulation phase
[134-467 pg/mL], luteal phases [75-351 pg/mL] and Menopause [1-17 pg/mL], PRG [male;[ 0.12-1.02
ng/mL]female: follicular phase [0.04-0.72 ng/mL], ovulation phase [0-5 ng/mL], luteal phases [0-0.38 ng/mL] and
Menopause [0-0.38 ng/mL], PRL [male;[ 0-17 ng/mL]female: menstrual [1.7-23 ng/mL] and menopausal [8-29
ng/mL]. Bleeding period [menstrual [2-5 days].Sex specific reference ranges for the assessment of fertility and
management of infertility disorders has been established. Age is an important factor in the interpretation of
testosterone hormone in males. In females, the ovarian and pituitary fertility hormones have different reference
ranges based on the phase of the menstrual cycle. These reference ranges are different from those reported in the
literature, therefore clinical chemistry laboratories within the same geographical region should establish their own
based on the population they serve
Description
Keywords
Hormones, Infertility, Kenyatta national hospital, Kenyan, Laboratory, Reference range