In Vivo Antidiabetic Activity of Aqueous Extract of Psidium Quajava in Alloxanised Diabetic Mice
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Date
2017
Authors
Njangiru, I.K.
Gitimu, M.R.
Njagi, E.N.M.
Journal Title
Journal ISSN
Volume Title
Publisher
Manuscript Central
Abstract
Introduction: Psidium quajava has for long been employed in the management of
many diseases in Kenya, including diabetes mellitus. However, the use of this
plant extract lacks scientific validation in regard to its efficacy. This study aimed
at investigating in vivo antidiabetic activity of aqueous extract of Psidium quajava
in alloxanized diabetic mice. Antidiabetic property was assessed through oral and
intraperitoneal administration of aqueous plants extract at doses of 50, 100, 200
and 300mg/kg body weight and profiling the levels of blood glucose after 0, 1, 2,
3, 4, 6 and 24 hours using a glucometer. The mineral composition of the aqueous
plant extract was assayed using Total Reflection X-ray Fluorescence system
(TRXF), while the different types of secondary metabolites were assessed using
standard procedures. The aqueous plant extract exhibited a dose dependent
hypoglycemic activity in alloxanized diabetic mice. The studied plant extract
contained alkaloids, flavonoids, saponins, tannins, and total phenols at varying
concentration. The mineral profile demonstrated the presence of detectable levels
of K, Ca, Ti, V, Mn, Fe, Ni, Cu, Zn and As. The plant’s aqueous extract was
effective in lowering blood glucose levels.
Description
Research Article
Keywords
Diabetes mellitus, Psidium quajava, Antidiabetic, Aqueous extract
Citation
Journal of Medical Biomedical and Applied Sciences volume 5 issue 1 2017