In Vivo Antidiabetic Effect of Aqueous Leaf Extract of Azardirachta indica, A. juss in Alloxan Induced Diabetic Mice
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Date
2016
Authors
Arika, W.M.
Nyamai, D.W.
Agyirifo, D.S.
Ngugi, M.P.
Njagi, E.N.M.
Journal Title
Journal ISSN
Volume Title
Publisher
OMICS International
Abstract
There is growing interest in the potential of plant remedies to treat and manage many diseases owing to the
adverse side effects, unavailability and unaffordability associated with the conventional therapy. Among the
traditional plants that has been prescribed for clinical use for many ailments including diabetes mellitus is
Azardirachta indica. Their continued use is largely based on their long-term therapeutic effects although this has not
been authenticated scientifically. This study therefore, aims to evaluate the in vivo hypoglycemic effect of aqueous
leaf extracts of A. indica in alloxan-induced white male albino mice. The blood glucose lowering effect of the extract
was intraperitoneally and orally bioscreened in diabetic mice in serial dilutions of the extract at 25 mg/kgbwt, 48.4
mg/kgbwt, 93.5 mg/kgbwt, 180.9 mg/kgbwt and 350 mg/kgbwt. Qualitative analysis of phytochemicals was done
using standard procedures. In both routes, the extract lowered blood glucose at all dosages in a dose independent
manner. The extracts contained flavonoids, tannins, sterols, saponins, anthraquinones and alkaloids. The
antidiabetic activity may be attributable to these phytochemicals present in the plant extract. The study confirms the
traditional use of this plant part in the treatment of diabetes mellitus. However, organic solvent extraction of the
leaves of this plant should be done to compare effects of both organic and aqueous fractions
Description
Research Article
Keywords
Azardirachta indica, Antidiabetic, Hyperglycemia, In vivo, Phytochemical, Insulin, Glibenclamide
Citation
Arika WM, Nyamai DW, Agyirifo DS, Ngugi MP, Njagi ENM (2016) In Vivo Antidiabetic Effect of Aqueous Leaf Extract of Azardirachta indica, A. juss in Alloxan Induced Diabetic Mice. J Diabetic Complications Med 1: 106. doi:10.4172/jdcm.1000.106