Show simple item record

dc.contributor.authorMwangi, B. M.
dc.contributor.authorGitahi, S. M.
dc.contributor.authorNjagi, J. M.
dc.contributor.authorMworia, J. K.
dc.contributor.authorAliyu, U.
dc.contributor.authorNjoroge, W. A.
dc.contributor.authorMwonjoria, K. J.
dc.contributor.authorNgugi, M. P.
dc.contributor.authorMburu, N. D.
dc.date.accessioned2015-07-21T09:33:44Z
dc.date.available2015-07-21T09:33:44Z
dc.date.issued2015
dc.identifier.citationInternational Journal of Current Pharmaceutical Research, Vol 7, Issue 3, pp.83-87;2015en_US
dc.identifier.issn0975-7066
dc.identifier.urihttp://ir-library.ku.ac.ke/handle/123456789/13189
dc.descriptionResearch Articleen_US
dc.description.abstractObjective: Inflammation is the reaction to injury of the living tissues. Conventional medication of inflammation is expensive and arguably associated with various severe adverse effects hence the need to develop herbal agents that are effective as alternative. Caesalpinia volkensii and Maytenus obscura are plants that grow in Mbeere County of Eastern region of Kenya. This study was designed to evaluate the anti-inflammatory activity of C. volkensii and M. obscura plants. Methods: Experimental animals were divided in to four groups; normal group, diseased negative control group, diseased reference group and diseased experimental groups. Inflammation was inducted into the mice using carrageenan. The experimental groups were treated with leaf extracts of the plants at the concentration of 50 mg/kg, 100 mg/kg and 150 mg/kg. Anti-inflammatory activities in rats were compared with diclofenac (15 mg/kg) as the standard conventional drug. Results: The leaf extracts of C. volkensii reduced paw edema by between 6.50%-13.42% while the extracts of M. obscura reduced it by between 4.94%-22.36%. Diclofenac reduced paw edema by between 4.11%-10.47%. Conclusion: The phytochemical screening results showed that the extracts of C. volkensii had flavonoids, steroids and phenolics while the leaf extracts M. obscura had phenolics, terpenoids and saponins. Flavonoids, saponins and phenolics have been associated with anti-inflammatory activities. Therefore, the study has established that the DCM: methanolic leaf extracts of Caesalpinia volkensii and Maytenus obscura are effective in management of inflammation.en_US
dc.language.isoenen_US
dc.publisherIJCPRen_US
dc.subjectCaesalpinia volkensiien_US
dc.subjectMaytenus obscuraen_US
dc.subjectLeaf extractsen_US
dc.subjectEdemaen_US
dc.subjectCarrageenanen_US
dc.titleAnti-inflammatory Properties of Dichloromethane: Methanolic Leaf Extracts of Caesalpinia Volkensii and Maytenus Obscura in Animal Modelsen_US
dc.typeArticleen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record