RP-Department of Pathology
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Browsing RP-Department of Pathology by Author "Gakinya, S."
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Item Incidence of perineural invasion in prostate adenocarcinoma: Rural Kenyan population experience(Kenyatta University, 2014) Nzioka, A.l.; Onyuma, T.; Gakinya, S.Introduction: Prostate cancer appears to be more aggressive amongst patients of African descent, a condition which could be associated with the presence of perineural invasion and higher Gleason scores of the cancer. Objective: This study evaluated the incidence of perineural invasion in previously diagnosed prostate cancer cases in a rural hospital which receive numerous cases of prostate cancer annually. Setting: This was a retrospective cross sectional study conducted at a busy mission referral hospital in rural Kenya. A total of 151 cases were included in the study. Patients' biodata was retrieved from the laboratory information system. Hematoxylin and eosin stained slides of previously diagnosed cases of prostate cancer over a period of one year (January 2012 to December 2012) were retrieved. These slides were microscopically examined for perineural invasion and the tumour grade determined using Gleason sconng. Results: Specimens from 151 patients were examined for perineural invasion. The patients' ages ranged from 46 to 93, mean age 73.77 (SD 9.474).Tumours in high grade category were 75.5% of the total number of cases while the rest (24.5%) were intennediatellow grade tumours. Out of these, 55.6% of the biopsies had perineural invasion. There was no significant relationship between the patients' age and the grade of tumour. Data on comparison of the cancers with perineural invasion and those without perineural invasion for grade demonstrated significant association between the tumour grade and the presence of perineural invasion (p:::;O.OOOI).Item Mammary analogue secretory carcinoma of the salivary gland of a recently described tumour: A case report(Kenyatta University School of Medicine, 2015) Nzioka, A.; Onyuma, P.; Gakinya, S.Mammary Analogue Secretory Carcinoma (MASC) is a recently described tumour of the salivary gland, characterized by the t (12; 15) (p13; q25) translocation. We report a case from a 40 year old female who presented with a tumour in the right parotid gland at Social Service League, MP Shah Hospital in Kenya. Histological evaluation, immunohistochemical staining and fluorescent in situ hybridization (FISH) were done. The findings were consistent with mammary analogue secretory carcinoma of the salivary gland. It is important to distinguish this tumour from its morphological mimics. At the time of writing of this paper, we believed that this is the first case of mammary analogue secretory carcinoma described in Kenya.