RP-Department of Medical Laboratory Sciences
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Browsing RP-Department of Medical Laboratory Sciences by Author "Kinyua, Martin"
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Item Antibiotic Susceptibility Pattern among Male Patients with Urinary Tract Infection in Special Treatment Centre, Nairobi County, Kenya.(International Journal of Advanced Multidisciplinary Research and Review (IJAMRR), 2019) Moraa, Dinah; Mathenge, Scholastica; Arodi, Washington; Torome, Tom; Mbuthia, Oliver; Kinyua, MartinThe occurrence of urinary tract infections in men can be very serious although not very common. Antibiotic resistance is becoming a global concern and Kenya is no exception. The aim and objective of the study was to investigate the causative bacteria and antibiotic susceptibility patterns among male patients with urinary tract infection visiting Special Treatment Centre, Nairobi County. Method: A descriptive cross-sectional study design was adopted from January 2018 to March 2018. Three hundred and eighty four (384) participants were recruited into the study using systematic sampling technique using structured questioners. Clean morning midstream urine was then cultured on Cysteine-Lactose-Electrolyte Deficient (CLED) agar and blood agar medium as per the standard urine culture. Antibiotic sensitivity test was then done on Mueller-Hinton agar using Kirby-Bauer disk diffusion method according to CLSI guidelines. Appropriate biochemical tests were done to identify the isolated bacteria. Results: The highest number of isolates was found to be Escherichia coli isolates (105) and the least was Pseudomonas auroginosa (12). Ofloxacin, 113(45.2) was found to be most effective antibiotic (x²=18.2, p=0.01) and the least effective being Augmentin (x²=1.56, p=0.811). Resistance was found to be high to Nitrofurantoin (65%) and least to Oflocaxin (13%). Conclusion: Bacterial cultures and sensitivity should be done on all cases of UTI’s to determine causative agents so as to guide clinicians in determining the most appropriate treatment. This will help in addressing cases of emerging multidrug resistance to the commonly used antibiotics. Follow-up of treated individuals to determine effectiveness of treatment would also help in addressing cases of failed treatment and prevention of resistance.