Warburgia Ugandensis: A Potent in Vivo Phytomedicine Against Plasmodium Knowlesi
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Date
2020
Authors
Were, Patrick Simiyu
Kutima, Helen Lydia
Suba, Hastings Ozwara
Walyambillah, Waudo
Journal Title
Journal ISSN
Volume Title
Publisher
Journal of Pharmacognosy and Phytochemistry
Abstract
Resistance to artemisinin-based therapies by Plasmodium falciparum and the entry of P. knowlesi as the fifth human malaria parasite present an urgent need for development of safe, affordable and effective therapeutic alternatives. Warburgia ugandensis, commonly used in herbal medicine, has displayed remarkable antiplasmodial properties. To be accepted as viable alternatives, herbal medicines must be subjected to the modern rigorous testing and validation procedures as used in convention medicines. This study was designed to determine the efficacy and safety of extracts from W. ugandensis. Plasmodium knowlesi-infected baboons were treated with an oral dose of 5000 mgkg-1/birth weight. Changes in parasiteamia, heamatology and biochemistry were recorded over a period of 21 days. Data were managed using GraphPad Prism Version 5.00. ANOVA for calculated means between treated and untreated animals (P-value < 0.0001) were separated by Tukeys’ Multiple Comparison for significance. Low parasiteamia and increased survivorship were observed in treated animals.
Description
Article
Keywords
Phytomedicine, Warburgia ugandensis, Papio anubis, Plasmodium knowlesi
Citation
Were, P. S., Kutima, H. L., Suba, H. O., & Walyambillah, W. (2020). Warburgia ugandensis: A potent in vivo phytomedicine against Plasmodium knowlesi. Journal of Pharmacognosy and Phytochemistry, 9(5), 01-05.