Hypoglycemic effect of Helichrysum odoratissimum in alloxan induced diabetic mice

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dc.contributor.authorNjagi, J.M.
dc.contributor.authorPiero, N.M.
dc.contributor.authorKibiti, Cromwell Mwiti
dc.contributor.authorNgeranwa, J.J.N.
dc.contributor.authorNjue, W. M.
dc.contributor.authorGathumbi, Peter
dc.contributor.authorNjagi, E.N.M.
dc.date.accessioned2015-03-24T13:06:05Z
dc.date.available2015-03-24T13:06:05Z
dc.date.issued2015
dc.description.abstractDiabetes mellitus is a disease of antiquity with worrying global incidence and prevalence. Conventional management and/or treatment interventions have been hampered by drawbacks like high costs, inaccessibility, likelihood of potential adverse and toxic effects among others. Use of antidiabetic phytodrugs has been on the rise, particularly in the developing countries, perhaps due to cost implications and accessibility advantages. In this study, an aqueous leaf extract of the medicinal plant Helichrysum odoratissimum was bioscreened for their hypoglycemic potential in alloxan-induced diabetic mice. Three dose ranges were used viz; 50 mg/kgbwt, 100 mg/kgbwt and 150 mg/kgbwt. Results indicate that the extract appreciably lowered blood glucose level in the diabetic mice. The glucose lowering potency of this extract was dose dependent. Preliminary in vivo toxicity assessment revealed that the plant has no discernible toxicity on the major organs of the study animals. The study results confirm the folklore reports from traditional medical practitioners that the extract has safe bioactivity against diabetes mellitus. It avails an impetus for further bioscreening efforts with a view to the development of more hypoglycemic agents in future.en_US
dc.description.sponsorshipThis study was undertaken in Kenyatta University and the University of Nairobi, for which reason they are hereby acknowledged. Moral and material support availed by the Late Solomon Buleti, Mr. Mugeki, Mrs. Rose Gitari and Mr. Jackson Gachoka is acknowledged with gratitude.en_US
dc.identifier.citationThe Journal of Phytopharmacology 2015; 4(1): 30-33en_US
dc.identifier.urihttps://www.researchgate.net/publication/273838619_Hypoglycemic_effect_of_Helichrysum_odoratissimum_in_alloxan_induced_diabetic_mice
dc.identifier.urihttp://ir-library.ku.ac.ke/handle/123456789/12412
dc.language.isoenen_US
dc.subjectDiabetes mellitusen_US
dc.subjectDiabetic miceen_US
dc.subjectIn-vivo toxicityen_US
dc.subjectAqueous leaf extracten_US
dc.titleHypoglycemic effect of Helichrysum odoratissimum in alloxan induced diabetic miceen_US
dc.typeArticleen_US
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