A Cross-Sectional Study of the Association between Autoantibodies and Qualitative Ultrasound Index of Bone in an Elderly Sample without Clinical Autoimmune Disease
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Date
2018
Authors
Iseme, Rosebella A
Mcevoy, Mark
Kelly, Brian
Agnew, Linda
Walker, Frederick R
Boyle, Michael
Attia, John
Journal Title
Journal ISSN
Volume Title
Publisher
Hindawi
Abstract
Bone loss is characteristic of the ageing process and a common complication of many autoimmune diseases. Research has
highlighted a potential role of autoantibodies in pathologic bone loss. The confounding effects of immunomodulatory drugs
make it difficult to establish the contribution of autoantibodies amongst autoimmune disease sufferers. We attempted to
examine the relationship between autoantibodies and bone mass in a population of 2812 elderly participants without clinical
autoimmune disease. Serum samples were assayed for a panel of autoantibodies (anti-nuclear, extractable nuclear antigen, antineutrophil cytoplasmic, thyroid peroxidase, tissue transglutaminase, anti-cardiolipin, rheumatoid factor, and cyclic citrullinated
peptide). Bone mass was measured using quantitative ultrasound (QUS) of the calcaneus. The relationship between each
autoantibody and bone mass was determined using linear regression models. Anti-nuclear autoantibodies were the most
prevalent, positive in approximately 11%, and borderline in roughly 23% of our sample. They were also the only autoantibody
observed to be significantly associated with QUS index in the univariate analysis (n = 1628; r = −0 20; 95% CI: −0.40–0.00;
p = 0 046). However, statistical significance was lost after adjustment for various other potential confounders. None of the other
autoantibodies was associated with QUS index in either univariate or multivariate analysis. We are limited by the cross-sectional
nature of the study and the low prevalence of autoantibodies in our nonclinical sample.
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Citation
Iseme, R. A., McEvoy, M., Kelly, B., Agnew, L., Walker, F. R., Boyle, M., & Attia, J. (2018). A cross-sectional study of the association between autoantibodies and qualitative ultrasound index of bone in an elderly sample without clinical autoimmune disease. Journal of Immunology Research, 2018.