Toxicity of Individual and Blends of Pure Phytoecdysteroids Isolated from Vitex Schiliebenii and Vitex Payos against Anopheles Gambiae S.S. Larvae

Simple item page
dc.contributor.authorNyamoita, M.G.
dc.date.accessioned2013-12-04T14:45:07Z
dc.date.available2013-12-04T14:45:07Z
dc.date.issued2013-02
dc.descriptionDOI: 10.12691/wjoc-1-1-1en_US
dc.description.abstractFour phytoecdysteroids: (20-hydroxyecdysone-20, 22-monacetonide (1), 20-hydroxyecdysone (2), stigmasterol (3), gamma-sitosterol (4), were investigated for toxic effect against 3rd /4th instar larvae of Anopheles gambiae under laboratory conditions as individual compounds and in blends. The test larvae were treated with solutions containing the phytoecdysteroids of concentrations 1, 5 and 10ppm. The blends were prepared in the ratio of 1:1. Compounds 1 and 2, isolated from acetone extracts of Vitex payos caused 100% mortality at 10ppm. Compound 3 isolated from acetone leaves of V. schiliebenii and compound 4 isolated from acetone stem bark of V. schilebenii also showed potent activity against the larvae at 10ppm. At the lower concentrations, abnormal mobility and impaired development was observed. Phytoecdysteroids (20-hydroxyecdysone-20, 22-monacetonide (1) and 20-hydroxyecdysone (2) are larvicidal against An. gambiae. stigmasterol (3), gamma-sitosterol (4) also show potent IGR activities against An. gambiae. Also addition of compounds 1 and 2 to stigmasterol (3) and gamma-sitosterol (4) seperately improved the activity of the two compounds.en_US
dc.identifier.citationWorld Journal of Organic Chemistry, 2013 1 (1), pp 1-5.en_US
dc.identifier.urihttp://ir-library.ku.ac.ke/handle/123456789/7799
dc.language.isoenen_US
dc.publisherScience and Education Publishingen_US
dc.subjectAnopheles gambiaeen_US
dc.subjectPhytoecdysteroids vitex schiliebeniien_US
dc.subjectV. payosen_US
dc.titleToxicity of Individual and Blends of Pure Phytoecdysteroids Isolated from Vitex Schiliebenii and Vitex Payos against Anopheles Gambiae S.S. Larvaeen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Toxicity of Individual and Blends of Pure Phytoecdysteroids Isolated from Vitex Schiliebenii and Vitex Payos against Anopheles Gambiae S.S. Larvae.pdf
Size:
232.22 KB
Format:
Adobe Portable Document Format
Description:
full article
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
RP-Department of Pharmacy & Complementary / Alternative Medicine