Geographical and Linguistic Structure in the People of Kenya Demonstrated Using 21 Autosomal STRS

Simple item page
dc.contributor.authorMuinde, Jane Mbithe
dc.contributor.authorBhanu, Devi R. Chandra
dc.contributor.authorNeumann, Rita
dc.contributor.authorOduor, Richard Okoth
dc.contributor.authorKanja, Wangu
dc.contributor.authorKimani, Joseph Kagunda
dc.contributor.authorMutugi, Marion W.
dc.contributor.authorSmith, Lisa
dc.contributor.authorJobling, Mark A.
dc.contributor.authorWetton, Jon H.
dc.date.accessioned2024-01-30T06:06:22Z
dc.date.available2024-01-30T06:06:22Z
dc.date.issued2021-05
dc.descriptionArticleen_US
dc.description.abstractKenya is a diverse and populous nation that employs DNA evidence in its criminal justice system, and therefore requires reliable information on autosomal STR allele frequency variation across the country and in its many ethnic groups. In order to provide reference data and to assess population structure, we analysed the 21 autosomal STRs in the GlobalFiler multiplex in a sample of 510 indigenous Kenyans representing the country’s eight former provinces, 43 of its 47 counties, three main linguistic families and all 29 ethnic groups that each comprise >0.5% of the 2019 census population. The indigenous population originated from successive migrations of Cushitic, Nilotic and Bantu speaking groups who settled in regions that suited their distinctive sustenance lifestyles. Consequently, they now largely reside in a patchwork of communities with strong associations with particular counties and provinces and limited degrees of inter-group marriage, as shown by DNA donors’ ancestry details. We found significant genetic differentiation between the three Nilotic language sub-families, with Western Nilotes (the Luo ethnic group) showing greater similarity to the Bantu than the Southern and Eastern Nilotes which themselves showed closer affinity to the Cushitic speakers. This concurs with previous genetic, linguistic and social studies. Comparisons with other African populations also showed that linguistic affiliation is a stronger factor than geography. This study revealed several rare off-ladder alleles whose structure was determined by Sanger sequencing. Among the unusual features that could affect profile interpretation were a deletion of Amelogenin Y but no other forensic marker (autosomal or Y-chromosomal), a triallelic pattern at TPOX and an extremely short SE33 allele falling within the expected size range of D7S820. Compared with the currently implemented Identifiler multiplex, Random Match Probabilities decreased from 6.4 × 10–19 to 3.9 × 10–27. The appreciation of local population structure provided by the geographically and ethnically representative sample in this study highlights the structured genetic landscape of Kenyaen_US
dc.identifier.citationMuinde, J. M., Bhanu, D. R. C., Neumann, R., Oduor, R. O., Kanja, W., Kimani, J. K., ... & Wetton, J. H. (2021). Geographical and linguistic structure in the people of Kenya demonstrated using 21 autosomal STRs. Forensic Science International: Genetics, 53, 102535.en_US
dc.identifier.urihttps://doi.org/10.1016/j.fsigen.2021.102535
dc.identifier.urihttps://ir-library.ku.ac.ke/handle/123456789/27325
dc.language.isoenen_US
dc.publisherElsevier B.Ven_US
dc.subjectKenyaen_US
dc.subjectAutosomal STRsen_US
dc.subjectPopulation structureen_US
dc.subjectLinguistic structureen_US
dc.subjectGlobalFileren_US
dc.titleGeographical and Linguistic Structure in the People of Kenya Demonstrated Using 21 Autosomal STRSen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Geographical and linguistic structure in the people of Kenya demonstrated.pdf
Size:
1.42 MB
Format:
Adobe Portable Document Format
Description:
Fulltext article
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
RP-Department of Plant and Microbial Sciences