Association of Interferon-gamma Responses to Pre-erythrocytic Stage Vaccine Candidate Antigens of Plasmodium Falciparum in Young Kenyan Children with Improved Hemoglobin Levels: XV. Asembo Bay Cohort Project.

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dc.contributor.authorOng'echa, J. M.
dc.contributor.authorLal, A. A.
dc.contributor.authorTerlouw, D. J.
dc.contributor.authorTer Kuile, F. O.
dc.contributor.authorKariuki, S. K.
dc.contributor.authorUdhayakumar, V.
dc.contributor.authorOrago, A. S.
dc.contributor.authorHightower, A. W.
dc.contributor.authorNahlen, B. L.
dc.contributor.authorShi, Y. P..
dc.date.accessioned2014-01-21T08:11:01Z
dc.date.available2014-01-21T08:11:01Z
dc.date.issued2003-05
dc.description.abstractPrevious studies in animal models have revealed an association between interferon-gamma (IFN-gamma), produced by CD8+ T cells and irradiated sporozoite-induced sterile immunity. To determine whether IFN-gamma can serve as a marker of pre-erythrocytic protective immunity in individuals naturally exposed to malaria, we characterized IFN-gamma and lymphocyte proliferative responses to previously defined CD8+ cytotoxic T lymphocyte (CTL) epitopes from six pre-erythrocytic stage antigens in 107 children six months to two years old from a community-based birth cohort in western Kenya. We found that IFN-gamma positive responders had higher hemoglobin (Hb) levels and significantly reduced prevalence of severe malarial anemia one month after the test compared with IFN-gamma non-responders, suggesting that IFN-gamma immune responses to these pre-erythrocytic antigens were associated with protection against malarial anemia. Children who responded by lymphocyte proliferation had a significantly longer time to first documented malaria parasitemia after birth; however, there was no correlation between the presence of lymphocyte proliferative response and higher Hb levels. We propose that IFN-gamma production could be used as a potential marker of protective immunity against malaria associated anemia in young children living in malaria holoendemic areas.en_US
dc.identifier.citationAm J Trop Med Hyg. 2003 May;68(5):590-7.en_US
dc.identifier.urihttp://ir-library.ku.ac.ke/handle/123456789/8733
dc.language.isoenen_US
dc.publisherThe American Journal of Tropical Medicine and Hygieneen_US
dc.titleAssociation of Interferon-gamma Responses to Pre-erythrocytic Stage Vaccine Candidate Antigens of Plasmodium Falciparum in Young Kenyan Children with Improved Hemoglobin Levels: XV. Asembo Bay Cohort Project.en_US
dc.typeArticleen_US
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