Concentrations of isometamidium chloride (SamorinĀ®) in sera of Zebu cattle which showed evidence of hepatotoxicity following frequent trypanocidal treatments

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dc.contributor.authorEisler, M.C.
dc.contributor.authorStevenson, P.
dc.contributor.authorMunga, L.K.
dc.contributor.authorSmyth, J.B.A
dc.date.accessioned2014-07-17T13:46:09Z
dc.date.available2014-07-17T13:46:09Z
dc.date.issued1997
dc.descriptionDOI: 10.1111/j.1365-2885.1997.tb00092.xen_US
dc.description.abstractThe concentrations of isometamidium circulating in poorly nourished Zebu cattle which showed morbidity, mortality, and biochemical and histopathological evidence of hepatotoxicity, following frequent treatments with isometamidium chloride and diminazene aceturate were investigated using the isometamidium-ELISA. As few as two isometamidium treatments one month apart were associated with significant weight loss, and cattle treated with diminazene aceturate after three or four isometamidium treatments suffered a 50% mortality. Although there were no obvious, marked elevations in isometamidium concentration which might have allowed the use of the ELISA as a predictor of a potential toxicity problem, concentrations did increase significantly with the number of monthly treatments administered, suggesting drug accumulation, and the increases were significantly higher in cattle to which diminazene had also been administered. In cattle treated with both trypanocides, weight loss and serum glutamate dehydrogenase levels were correlated with isometamidium concentrations. These observations, together with the histopathological findings, support the hypothesis that the morbidity and mortality observed were related to the repeated treatment with isometamidium in conjunction with diminazene aceturate, and that the pathogenesis involved a component of hepatic damage. It is therefore recommended that cattle, particularly those under nutritional stress, are not subjected to repeated treatments with isometamidium at intervals as short as one month, and particularly not with concurrent administration of diminazene.en_US
dc.identifier.citationJournal of Veterinary Pharmacology and Therapeutics 20, 173-180, 1997.en_US
dc.identifier.issn0140-7783
dc.identifier.other1365-2885
dc.identifier.urihttp://onlinelibrary.wiley.com/store/10.1111/j.1365-2885.1997.tb00092.x/asset/j.1365-2885.1997.tb00092.x.pdf?v=1&t=hxq4isso&s=b431febd1759d15eaf3675690fd105f93440786b
dc.identifier.urihttp://ir-library.ku.ac.ke/handle/123456789/10483
dc.language.isoenen_US
dc.publisherBlackwell Publishingen_US
dc.titleConcentrations of isometamidium chloride (SamorinĀ®) in sera of Zebu cattle which showed evidence of hepatotoxicity following frequent trypanocidal treatmentsen_US
dc.typeArticleen_US
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