Seroprevalence of Cytomegalo Virus (CMV) among pregnant women in Thika, Kenya

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dc.contributor.authorMaingi, Z.
dc.contributor.authorNyamache, A. K.
dc.date.accessioned2014-12-10T13:21:11Z
dc.date.available2014-12-10T13:21:11Z
dc.date.issued2014-11
dc.descriptiondoi: 10.1186/1756-0500-7-794en_US
dc.description.abstractBackground The fetal consequences of CMV infection have made it one of the most serious infections contracted during pregnancy. Despite the posed teratogenic risk during pregnancy, there is no national screening test for CMV infection is available during pregnancy in Kenya. Thus little is known on its epidemiological data that is necessary for health planners and care providers. Methods A cross sectional study was conducted at Thika district level 5 hospital, Kenya to investigate seroprevalence of CMV infections and associated possible risk factors among pregnant women. Structured questionnaires were used to gather socio-demographic data and ELISA was used to detect CMV infections using IgG and IgM. Results Out of 260 pregnant women, 201 (77.3%) were CMV IgG 21(8.1%) CMV IgM being on acute stage of the disease. Marital status (OR = 3.7533, 95% CI =3.0231-6.9631, P < 0.0001), parity (OR = 3.7533, 95% CI = 3.0231-6.9631, P < 0.0001), and education (OR = 3.7533, 95% CI = 3.0231-6.9631, P < 0.0001), history of blood transfusion (OR = 0.0374, 95% CI = 0.00120-0.1168, OR = 0.3804) were found to significantly influence seropostivity in univariate analysis. Conclusion The 88.4% CMV prevalence rate being detected among pregnant women calls for vaccine and routine screening for CMV infections and its associated risk factors in this kind of settings. Background The fetal consequences of CMV infection have made it one of the most serious infections contracted during pregnancy. Despite the posed teratogenic risk during pregnancy, there is no national screening test for CMV infection is available during pregnancy in Kenya. Thus little is known on its epidemiological data that is necessary for health planners and care providers. Methods A cross sectional study was conducted at Thika district level 5 hospital, Kenya to investigate seroprevalence of CMV infections and associated possible risk factors among pregnant women. Structured questionnaires were used to gather socio-demographic data and ELISA was used to detect CMV infections using IgG and IgM. Results Out of 260 pregnant women, 201 (77.3%) were CMV IgG 21(8.1%) CMV IgM being on acute stage of the disease. Marital status (OR = 3.7533, 95% CI =3.0231-6.9631, P < 0.0001), parity (OR = 3.7533, 95% CI = 3.0231-6.9631, P < 0.0001), and education (OR = 3.7533, 95% CI = 3.0231-6.9631, P < 0.0001), history of blood transfusion (OR = 0.0374, 95% CI = 0.00120-0.1168, OR = 0.3804) were found to significantly influence seropostivity in univariate analysis. Conclusion The 88.4% CMV prevalence rate being detected among pregnant women calls for vaccine and routine screening for CMV infections and its associated risk factors in this kind of settings.en_US
dc.description.sponsorshipThe study was funded from the accrued funds generated within the department of Medical laboratory sciences, Kenyatta University.en_US
dc.identifier.citationBMC Res Notes. 2014 Nov 12;7(1):794. doi: 10.1186/1756-0500-7-794.en_US
dc.identifier.issn1756-0500
dc.identifier.other1756-0500
dc.identifier.urihttp://www.biomedcentral.com/1756-0500/7/794
dc.identifier.urihttp://ir-library.ku.ac.ke/handle/123456789/11841
dc.language.isoenen_US
dc.publisherBioMed Centralen_US
dc.titleSeroprevalence of Cytomegalo Virus (CMV) among pregnant women in Thika, Kenyaen_US
dc.typeArticleen_US
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