In Vivo Hypoglycemic Effect of Kigelia africana (Lam): Studies With Alloxan-Induced Diabetic Mice
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Date
2018
Authors
Njogu, Stephen M.
Arika, Wycliffe M.
Machocho, Alex K.
Ngeranwa, Joseph J. N.
Njagi, Eliud N. M.
Journal Title
Journal ISSN
Volume Title
Publisher
SAGE Publications
Abstract
The claims by the traditional herbal medicine practitioners that Kigelia africana has bioactivity against several diseases, including
diabetes mellitus, were investigated in this study. Type I diabetes mellitus was induced in mice by intraperitoneal administration of
alloxan monohydrate followed by treatment with the therapeutic doses of the aqueous and ethyl acetate leaf extract of K africana
to the experimentally diabetic mice. The treatment effects were compared with the normal control, diabetic control, and diabetic
control rats treated with a standard antidiabetic drugs (insulin administered intraperitoneally at 1 IU/kg body weight in 0.1 mL
physiological saline or glibenclamide administered orally at 3 mg/kg body weight in 0.1 mL physiological saline). Phytochemical
composition of the leaf extract was assessed using standard procedures and mineral elements assessed using atomic absorption
spectrophotometry and total reflection X-ray fluorescence system. Oral and intraperitoneal administration of the aqueous and
ethyl acetate leaf extract caused a statistically significant dose-independent reduction in plasma glucose level in alloxan-induced
diabetic mice. The observed hypoglycemic activity of this plant extract could be attributed to the observed phytochemicals and
trace elements, which have been associated with exhibiting antidiabetic properties. Therefore, the data appear to support the
hypoglycemic effects of K africana validating its folkloric usage.
Description
Research Article
Keywords
Diabetes mellitus, Alloxan monohydrate, Oral and intraperitoneal, Antidiabetic, Hypoglycemic, Kigelia africana, Atomic absorption spectrophotometry (AAS), Total reflection X-ray fluorescence (TXRF)
Citation
Journal of Evidence-Based Integrative Medicine Volume 23: 1-10