Antibiotic Susceptibility Profile of the Klebsiella Pneumoniae Isolated from Africa Inland Church Hospital Kijabe, Kenya
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Date
2019
Authors
Mwangi, Joseph Kibuchi
Mathenge, Scholastica
Njoroge, Wachuka
Journal Title
Journal ISSN
Volume Title
Publisher
International Journal of Advanced Multidisciplinary Research
Abstract
The emergence of antimicrobial resistance is primarily due to excessive and often
unnecessary use of antibiotics in humans and animals. A study done in low and middle
income countries showed a considerable increasing resistance in Enterobacteriaceae (Ashley
et al., 2011). The data revealed that affordable first line agents such as ampicillin and
gentamicin are unlikely to be clinically efficacious in a substantial proportion of infections.
This results in increasing reliance on the third generation cephalosporins for empirical
treatment of serious infections. However, the spread of extended-spectrum beta-lactamase
producing strains into the community (Ashley et al., 2011), probably accelerated by this
increased consumption, is eroding the usefulness of these drugs. Alternative agents for
treating multi-resistant coliform infections, such as the carbapenems, are unaffordable for
treatment of community- acquired infections in low-income countries. The clinical
specimens which were used included; urine, aspirates, blood, cerebral spinal fluid (CSF),
swabs of wound, device swabbing. The design was a prospective observational. Ethical
approval was sought from the Kenyatta University ethical review committee and the Ethical
committee in AIC Kijabe hospital as attached. antimicrobial susceptibility among the 55
blood samples infected with K. pneumoniae showed that 100% was resistant to Ampicillin, 98% was resistant to Ceftadime, 86% was resistant to Ceftriaxone, 83% was resistant to
Cefazolin, and none of the isolates was resistant to Meropenem. To test whether the
difference in means in relation to antibiotics resistance in Klebsiella pneumoniae isolates
was significant, analysis of variance (ANOVA) statistic was used. This parametric test was
used to test the hypothesis that there is no antibiotics resistance in Klebsiella pneumoniae
isolates from AIC Kijabe hospital. The result of analysis indicated that there was
statistically significant difference among the means scores 5.547 at 0.05. It was concluded
that use of antibiotics has influence on effective management in Klebsiella pneumoniae
isolates from AIC Kijabe hospital. This study through its findings recommends that;
Regular antimicrobial audits and reviews of laboratory data (surveillance) should be done so
as to have proper documentation of drug resistance patterns and timely updates of antibiotic
formularies. The study focused on AIC Kijabe Hospital Kiambu County only, therefore, the
same study can be extended in other hospitals and other counties for comparison purposes
Description
An Article Published in International Journal of Advanced Multidisciplinary Research (IJAMR)
Keywords
Antimicrobial, Resistance, Susceptibility, Profile, Klebsiella pneumoniae