Cardio Protection and Antiatherosclerotic Effects of Solanumincanum (Lin.) Extracts in Animal Models
Loading...
Date
2025
Journal Title
Journal ISSN
Volume Title
Publisher
John Wiley & Sons Ltd
Abstract
Solanum incanum is a bushy perennial herb which is used for treatment of various ailments in East Africa including stomach pain,
toothaches, ulcers, and cardiovascular diseases. However, there is scarcity of data on its safety, and its efect on the physiology of
the cardiovascular system. Hence, this study envisaged evaluating the efect of methanol extract of the herb on myocardial action
atherosclerotic tendency and safety. Myocardial activity assay involved determination of the heart rate and force of contraction
using an isolated rabbit heart in an organ bath and kymograph, while antiatherosclerotic efects were assayed on blood obtained
from white Wistar rats fed on high lipid diet where the levels of low-density lipoproteins, high-density lipoproteins and total
cholesterol were determined. Assays of the toxic efects of the extract were carried out on Swiss albino mice while qualitative
phytochemical analyses were carried out using one-way Anova and Tukey as the post hoc test, a value of (p < 0.05) was taken as the
limit of signifcance. Te plant extracts exhibited an increase in the force of contraction of the heart and decrease in heart rate. It
also caused signifcant (p < 0.05) reduction in serum low-density lipoproteins and total cholesterol as well as elevation of HDL but
no efect on hematological parameters. Phytochemical analyses showed the presence of alkaloids, glycosides, saponins favonoids,
terpenoids, steroids, and phenolics. Hence, the S. incanum root extract may contain compounds with antiatherosclerotic efects
that are cardioprotective and therefore a potential source of novel remedies for the ailment
Description
Article
Keywords
Citation
Mburu, Stephen Ngigi, Mathew Piero Ngugi, and John K. Mwonjoria. "Cardio Protection and Antiatherosclerotic Effects of Solanum incanum (Lin.) Extracts in Animal Models." Scientifica 2025.1 (2025): 5594777.