A 4-Alkyl-substituted Analogue Of Guaiacol Shows Greater Repellency To Savannah Tsetse (Glossina spp.)
| dc.contributor.author | Hassanali, Ahmed | |
| dc.contributor.author | Saini, R. K. | |
| dc.date.accessioned | 2014-02-28T11:44:00Z | |
| dc.date.available | 2014-02-28T11:44:00Z | |
| dc.date.issued | 2007-05 | |
| dc.description | DOI 10.1007/s10886-007-9272-7 | en_US |
| dc.description.abstract | The responses of Glossina morsitans morsitans Westwood to guaiacol (2-methoxyphenol), a mild repellent constituent of bovid odors, and seven analogues comprising 2-methoxyfuran, 2,4-dimethylphenol, 2-methoxy-4-methylphenol (4-methylguaiacol), 4-ethyl-2-methoxyphenol (4-ethylguaiacol), 4-allyl-2-methoxyphenol (4-allylguaiacol; eugenol), 3,4-methylenedioxytoluene, and 3,4-dimethoxystyrene were compared in a two-choice wind tunnel. The 4-methyl-substituted derivative (2-methoxy-4-methylphenol) was found to elicit stronger repellent responses from the flies compared with guaiacol. None of the other analogues showed significant repellent effects on flies. 4-Methylguaiacol, guaiacol, and eugenol (which was included because of previous reports of its repellency against a number of arthropods) were further evaluated in the field with wild populations of predominantly Glossina pallidipes Austen. The presence of guaiacol or eugenol near odor-baited traps caused some nonsignificant reduction in the number of tsetse catches at relatively high release rates (∼50 mg/hr). In contrast, the 4-methyl derivative at three different release rates (2.2, 4.5, and 9.0 mg/hr) reduced trap catches of baited traps in a dose-response manner. At 10 mg/hr release rate, it reduced the catches of baited and unbaited traps by ∼80 and ∼70%, respectively. In addition, the compound not only reduced the number of tsetse attracted to natural ox odor (∼ 80%), but also had an effect on their feeding responses, reducing the proportion that fed on an ox by more than 80%. Our study shows that the presence of a methyl substituent at the 4-position of guaiacol enhances the repellency of the molecule to savannah tsetse and suggests that 4-methylguaiacol may represent a promising additional tool in the arsenal of techniques in trypanosomiasis control. | en_US |
| dc.identifier.citation | Journal of Chemical Ecology May 2007, Volume 33, Issue 5, pp 985-995 | en_US |
| dc.identifier.issn | 1573-1561 | |
| dc.identifier.uri | http://ir-library.ku.ac.ke/handle/123456789/9129 | |
| dc.language.iso | en | en_US |
| dc.publisher | Springer-Verlag | en_US |
| dc.subject | Tsetse fly | en_US |
| dc.subject | Glossina pallidipes | en_US |
| dc.subject | Repellents | en_US |
| dc.subject | Behavior | en_US |
| dc.subject | Trypanosomiasis | en_US |
| dc.subject | Guaiacol | en_US |
| dc.subject | 4-Methylguaiacol | en_US |
| dc.title | A 4-Alkyl-substituted Analogue Of Guaiacol Shows Greater Repellency To Savannah Tsetse (Glossina spp.) | en_US |
| dc.type | Article | en_US |