Bisbenzylisoquinoline and hasubanane alkaloids from Stephania abyssinica (Dillon & A. Rich) (Menispermeceae)

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dc.contributor.authorHassanali, Ahmed
dc.contributor.authorOmole, R. A.
dc.contributor.authorMachocho, Alex K.
dc.contributor.authorNdiege, I. O.
dc.contributor.authorGathirwa, Jeremiah
dc.contributor.authorAkala, Hosea
dc.contributor.authorMalebo, Hamisi M.
dc.date.accessioned2014-11-25T07:52:13Z
dc.date.available2014-11-25T07:52:13Z
dc.date.issued2014-07
dc.descriptiondoi:10.1016/j.phytochem.2014.03.026en_US
dc.description.abstractTwo bisbenzylisoquinoline and one hasubanane alkaloids: (−)-pseudocurine (1), (−)-pseudoisocurine (2) and (−)-10-oxoaknadinine (3), were isolated from leaf extract of Stephania abyssinica, a plant used in traditional medicine in South Nyanza region of Kenya. They were characterized using 1D (1H, 13C and DEPT) and 2D (COSY, NOESY, HMQC and HMBC) NMR techniques. (−)-Pseudocurine (1) and (−)-pseudoisocurine (2) exhibited strong to moderate anti-plasmodial activity while (−)-10-oxoaknadinine (3) showed moderate to mild activity. ________________________________________ Graphical abstract From the leaves of Stephania abyssinica, three alkaloids were isolated: (−)-pseudocurine (1), (−)-pseudoisocurine (2) and (−)-10-oxoaknadinine (3). (−)-Pseudocurine and (-)-pseudoisocurine showed strong anti-plasmodial activity against both chloroquine-susceptible D6 and resistant strains of Plasmodium falciparum (IC50 0.29 ± 0.00 and 0.31 ± 0.01 μg/ml, respectively) while (−)-pseudoisocurine exhibited moderate and mild activity (0.75 ± 0.11 and 1.65 ± 0.03 μg/ml).en_US
dc.identifier.citationPhytochemistry Volume 103, July 2014, Pages 123–128en_US
dc.identifier.issn0031-9422
dc.identifier.issnhttp://www.researchgate.net/publication/261564919_Bisbenzylisoquinoline_and_hasubanane_alkaloids_from_Stephania_abyssinica_(Dillon__A._Rich)_(Menispermeceae)
dc.identifier.other1873-3700
dc.identifier.urihttp://ir-library.ku.ac.ke/handle/123456789/11730
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectMenispermerceaeen_US
dc.subjectStephania abyssinicaen_US
dc.subjectAlkaloidsen_US
dc.subjectBisbenzylisoquinolineen_US
dc.subject(−)-Pseudocurine and (−)-pseudoisocurineen_US
dc.subjectHasubananeen_US
dc.subject(−)-10-oxoaknadinine anti-plasmodial activityen_US
dc.titleBisbenzylisoquinoline and hasubanane alkaloids from Stephania abyssinica (Dillon & A. Rich) (Menispermeceae)en_US
dc.typeArticleen_US
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