Immunology of leishmaniasis

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dc.contributor.authorGicheru, M. M.
dc.contributor.authorMutiso, J. M.
dc.contributor.authorMacharia, J. C.
dc.contributor.authorOzwara, H.
dc.date.accessioned2014-07-02T12:02:58Z
dc.date.available2014-07-02T12:02:58Z
dc.date.issued2013-06
dc.description.abstractResolution of leishmanial infection is dependent on the coordinated interactions between components of cell mediated immune response, central to which is the activation of targeted T-cell populations for appropriate cytokine production and activation of infected cells. In human as well as murine leishmaniasis, cure is associated with predominant Th1 response, good cell-mediated immunity (CMI), production of interferon gamma (IFN-γ) and macrophage activation. On the other hand, cytokine analysis in visceral leishmaniasis reveals enhanced induction of IL-10 and⁄or IL-4 mRNA in tissues, poor CMI, hypergammaglobulinaemia and enhanced presence of IL-4 in circulation of patients with progressive disease. The Th1/Th2 paradigm of resistance/susceptibility is an oversimplication ofa far more complicated network of regulatory/counter-regulatory interactions and thus a deficit in the understanding of the exact mechanisms involved in resolution vs severity of leishmaniasis. This review, in additionto giving a general overview of basic immunology of Leishmania infection, consolidates findings on immune responses in experimental and human leishmaniasis. Such information is important in giving a feasible direction in designing prophylactic and therapeutic strategies against leishmaniasis.en_US
dc.identifier.citationScientia Parasitologica 14(2):51-61, June 2013en_US
dc.identifier.issn1582-1366
dc.identifier.urihttp://oris.nacosti.go.ke/modules/library/publications/research_reports/NACOSTI-DL-RR-1017.pdf
dc.identifier.urihttp://ir-library.ku.ac.ke/handle/123456789/10274
dc.language.isoenen_US
dc.subjectLeishmaniasisen_US
dc.subjectMurineen_US
dc.subjectHumanen_US
dc.subjectImmune responseen_US
dc.titleImmunology of leishmaniasisen_US
dc.typeArticleen_US
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