Larvicidal activity of Kotschya uguenensis plant powders and methanol extracts against Anopheles gambiae s.s. larvae in the laboratory and in simulated ponds

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dc.contributor.authorInnocent, E.
dc.contributor.authorNkunya, M. H. H.
dc.contributor.authorHassanali, A.
dc.date.accessioned2014-07-31T11:55:39Z
dc.date.available2014-07-31T11:55:39Z
dc.date.issued2013-02
dc.descriptionDOI: 10.7324/JAPS.2013.30221en_US
dc.description.abstractPolar constituents of Kotschya uguenensis Verdc. (Fabaceae) do not exhibit acute toxicity but cause growth disruption of Anopheles gambiae s.s. Gile (Diptera: Culicidae) larvae with eventual death. Time-course larvicidal effects of powders of root and stem barks and their crude methanol extracts in form of emulsions were compared in the laboratory and in artificial semi-field ponds. Kotschya uguenensis powders of root and stem barks and emulsions of their crude methanol extracts were assayed against A. gambiae s.s according to protocols of WHO 1996 & 2005. All formulations were equally effective under laboratory conditions giving 100% larval mortality within three days at a dose of 50 μg/ml of the extracts or concentrations of powders corresponding to the same level of extractable material. Under semi-field conditions, suspensions of the powder materials appeared to perform better than emulsions of methanol extracts. Time taken to give 80% mortality (LT80) of larvae and pupa at 0.1% w/v was 6.06 days for powders of root bark and 5.60 days for powders of stem bark. The LT80 for the root bark extract at 200 μg/ml was 8.28 days while that for the stem bark methanol extract was 12.47 days. No residual effects of the test materials on the larvae or pupae were evident in semi-field ponds 14 days after the re-introduction of the test materials. Our results suggest that, for the control of anophelines in the field, a weekly application of appropriate amounts of powders of K. uguenensis may be effective.en_US
dc.identifier.citationJournal of Applied Pharmaceutical Science Volume: 3, Issue: 2, February, 2013en_US
dc.identifier.issn2231-3354
dc.identifier.urihttp://www.japsonline.com/admin/php/uploads/798_pdf.pdf
dc.identifier.urihttp://ir-library.ku.ac.ke/handle/123456789/10785
dc.language.isoenen_US
dc.titleLarvicidal activity of Kotschya uguenensis plant powders and methanol extracts against Anopheles gambiae s.s. larvae in the laboratory and in simulated pondsen_US
dc.typeArticleen_US
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