Suppression of RANTES in children with Plasmodium falciparum malaria.

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dc.contributor.authorWere, T.
dc.contributor.authorHittner, James B.
dc.contributor.authorOuma, C.
dc.contributor.authorOtieno, Richard O.
dc.contributor.authorOrago, A. S.
dc.contributor.authorOng'echa, J. M.
dc.contributor.authorVulule, J. M.
dc.contributor.authorKeller, C. C.
dc.contributor.authorPerkins, D. J.
dc.date.accessioned2013-11-13T12:44:53Z
dc.date.available2013-11-13T12:44:53Z
dc.date.issued2006-10
dc.description.abstractSevere malarial anemia (MA) is the primary manifestation of severe malaria among children in areas of holoendemic Plasmodium falciparum transmission. Although overproduction of inflammatory-derived cytokines are implicated in the immunopathogenesis of severe MA, chemokines such as regulated on activation, normal T-cell expressed and secreted (RANTES, CCL5) are largely unexplored in childhood malaria. We found that RANTES is decreased during severe MA (p<0.01), and associated with suppression of erythropoiesis (p<0.05) and malaria-induced thrombocytopenia (p<0.05). These findings suggest that thrombocytopenia may be a source of reduced RANTES which may contribute, at least in part, to suppression of erythropoiesis in children with malarial anemia.en_US
dc.identifier.citationHaematologica. 2006 Oct;91(10):1396-9.en_US
dc.identifier.urihttp://ir-library.ku.ac.ke/handle/123456789/7619
dc.language.isoenen_US
dc.publisherHaematologicaen_US
dc.titleSuppression of RANTES in children with Plasmodium falciparum malaria.en_US
dc.typeArticleen_US
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