Antimicrobial Photodynamic Activity of Phthalocyanine Derivatives

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dc.contributor.authorNyamu, Samuel N
dc.contributor.authorOmbaka, Lucy
dc.contributor.authorMasika, Eric
dc.contributor.authorNg’ang’a, Margaret
dc.date.accessioned2023-07-19T12:40:33Z
dc.date.available2023-07-19T12:40:33Z
dc.date.issued2018
dc.descriptionArticleen_US
dc.description.abstractMicrobial pathogens have increasingly shown multidrug resistance posing a serious threat to the public health. Advances in technology are opening novel avenues for discovery of compounds that will mitigate the ever-increasing drug-resistant microbes. Use of photodynamic photosensitizer is one of the promising alternative approaches since they ofer low risk of bacteria resistance as they use generated reactive oxygen species to kill the microbes. Phthalocyanine (Pc) is one such photosensitizer which has already shown promising antimicrobial photodynamic therapeutic properties. Previous studies have shown efectiveness of the Pc against Gram-positive bacteria. However, its efectiveness toward Gram-negative bacteria is limited by the impermeability of the bacteria’s outer membrane which is made up of lipopolysaccharides layer. Te efectiveness of this photosensitizer is determined by its photophysical and photochemical properties such as singlet/triplet lifetimes, singlet oxygen quantum yields, and fuorescence quantum yield. Terefore, this review focuses on the recent signifcance advances on designing Pc that have this improved property by either conjugating with nanoparticles, quantum dots, functional groups in peripheral position, considering efect of cationic charge, and its position on the macrocycle.en_US
dc.identifier.citationNyamu, S. N., Ombaka, L., Masika, E., & Ng’ang’a, M. (2018). Antimicrobial photodynamic activity of phthalocyanine derivatives. Advances in Chemistry, 2018.en_US
dc.identifier.otherhttps://doi.org/10.1155/2018/2598062
dc.identifier.urihttp://ir-library.ku.ac.ke/handle/123456789/26325
dc.language.isoenen_US
dc.publisherHindawien_US
dc.titleAntimicrobial Photodynamic Activity of Phthalocyanine Derivativesen_US
dc.typeArticleen_US
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