Biflavonoids from an Ethno-Medicinal Plant Ochna holtzii Gilg

Simple item page
dc.contributor.authorHassanali, Ahmed
dc.contributor.authorMachocho, Alex K.
dc.contributor.authorAwadh, M.M.
dc.contributor.authorTarus, P.K.
dc.contributor.authorOnani, M. O.
dc.date.accessioned2015-01-20T09:10:13Z
dc.date.available2015-01-20T09:10:13Z
dc.date.issued2014
dc.descriptionArticleen_US
dc.description.abstractOchna holtzii Gilg is a medicinal plant used extensively at the Kenya Coast for the treatment of various ailments. From solvent extracts of the root and stem barks of O. holtzii, seven constituents were isolated by standard chromatographic techniques (CC, VLC, prep-TLC and Sephadex LH-20). Their structures were analyzed by MS, UV,IR,1D and 2D NMR spectroscopy. All were found to be biflavonoids, including three novel compounds: dehydrate of lophirone C, hotzinol, and tri-O-methyl lophirone A. Crude methanol extracts of O. holtzii and the isolated biflavonoids were tested for antimicrobial activities against two Gram-positive bacteria, Staphylococcus aureus and Bacillus subtilis, two Gram-negative bacteria, Salmonella typhi and Pseudomonas aeruginosa, and the diploid fungus Candida albicans. The extracts and the isolated constituents showed varying levels of activities against the microbes. Afzelone D, lophirone A and the novel tri-O-methyl lophirone A showed strong activities against P. aeruginosa and S. aureus, with the latter being more susceptible. Calodenin B and the novel dehydrolophirone C also showed strong activities against these bacteria, but were more active against P. aeruginosa. However, none of these matched those of the antibiotic Chloramphenicol or the antifungal Fluconazole. This represents the first study on phytochemical and antimicrobial profiles of O. holtzii.en_US
dc.description.sponsorshipKenyatta University and its technical staff for providing space and some apparatus used in this work. AICAD (the African Institute for Capacity Development) for partial funding of the project. Mr. Lucas Karimi, Department of Pharmacy and Complementary Medicine for authenticating the plant.en_US
dc.identifier.citationAwadh, Nat Prod Chem Res 2014, 2:6 http://dx.doi.org/10.4172/2329-6836.1000149en_US
dc.identifier.urihttp://ir-library.ku.ac.ke/handle/123456789/11991
dc.language.isoenen_US
dc.publisherOMICS Publishing Groupen_US
dc.subjectAfzelone D O-methyletheren_US
dc.subjectHoltzinolen_US
dc.subjectDehydrolophirone Cen_US
dc.subjectBiflavonoidsen_US
dc.subjectOchnaceaeen_US
dc.subjectOchnaholtzii Gilen_US
dc.titleBiflavonoids from an Ethno-Medicinal Plant Ochna holtzii Gilgen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
biflavonoids-from-an-ethnomedicinal-plant-ochna-holtzii-gilg-2329-6836.1000149.pdf
Size:
556.51 KB
Format:
Adobe Portable Document Format
Description:
full article
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
RP-Department of Chemistry