Association between Malnutrition and Immunoglobulin G Responses to Crude Asexual P. falciparum schizont Lysates in Children Attending Ishiara Hospital, Embu County, Kenya

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dc.contributor.authorMungiria, Juster
dc.contributor.authorGicheru, M. M.
dc.contributor.authorKavili, David
dc.contributor.authorMburu, David
dc.date.accessioned2017-06-16T10:03:02Z
dc.date.available2017-06-16T10:03:02Z
dc.date.issued2017
dc.descriptionResearch Articleen_US
dc.description.abstractAim: The aim of this study was to determine levels of Plasmodium falciparum parasitaemia in children and relationship between IgG responses against the parasite and nutritional status of children. Study Design: Cross sectional study of children diagnosed positive for P. faciparum in Ishiara District Hospital, Embu county, Kenya was done between August 2011 and June 2012. Methodology: A total of 380 children, under 5 years who tested positive to P. faciparum infection were used for the study. Children with less than -2 Z score of height-for-age were classified as stunted and those with less than -2 Z score of weight-for-height were classified as wasted. Malnourished children were identified by the criteria of WHO. P. faciparum parasitaemia was determined by microscopy, using Giemsa stained thin and thick blood smears while the parasite`s IgG antibody responses were assessed by the Enzyme linked immune-sorbent assay. Results: Of the 380 children 70% were malnourished. Of the malnourished children 30% were stunted, 37% wasted while 3% were both stunted and wasted. Well-nourished children had mean parasitaemia of 530 per micro litre which was lower (P0,05). IgG responses of well nourished children (1.9) was higher than 1.2 of wasted children (r=0.7. P< 0.05) and also between the well-nourished and those both stunted and wasted (r = -0.8; P < 0.05). Conclusion: This study showed that malnutrition reduces IgG responses of children below 5 years to P. falciparum infection and predisposes them to malaria.en_US
dc.identifier.citationJuster et al.; JALSI, 11(1): 1-14, 2017; Article no.JALSI.31041en_US
dc.identifier.issn2394-1103
dc.identifier.urihttp://www.journalrepository.org/media/journals/JALSI_40/2017/Apr/Juster1112016JALSI31041.pdf
dc.identifier.urihttp://ir-library.ku.ac.ke/handle/123456789/17666
dc.language.isoenen_US
dc.publisherSCIENCEDOMAIN Internationalen_US
dc.subjectMalariaen_US
dc.subjectMorbidityen_US
dc.subjectNutritionen_US
dc.subjectImmunityen_US
dc.subjectAnthropometryen_US
dc.subjectSchizont extracten_US
dc.subjectAntibodiesen_US
dc.subjectPlasmodiumen_US
dc.titleAssociation between Malnutrition and Immunoglobulin G Responses to Crude Asexual P. falciparum schizont Lysates in Children Attending Ishiara Hospital, Embu County, Kenyaen_US
dc.typeArticleen_US
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