The Implications of HIV treatment on the HIV-malaria coinfection dynamics: a modeling perspective
Loading...
Date
2015
Authors
Nyabadza, F.
Bekele, B. T.
RĂșa, M. A.
Malonza, D. M.
Chiduku, N.
Kgosimore, M.
Journal Title
Journal ISSN
Volume Title
Publisher
BioMed Central
Abstract
Most hosts harbor multiple pathogens at the same time in disease epidemiology. Multiple pathogens have the potential for
interaction resulting in negative impacts on host fitness or alterations in pathogen transmission dynamics. In this paper we develop
a mathematical model describing the dynamics of HIV-malaria coinfection. Additionally, we extended our model to examine the
role treatment (of malaria and HIV) plays in altering populationsâ dynamics. Our model consists of 13 interlinked equations which
allow us to explore multiple aspects of HIV-malaria transmission and treatment. We perform qualitative analysis of the model
that includes positivity and boundedness of solutions. Furthermore, we evaluate the reproductive numbers corresponding to the
submodels and investigate the long term behavior of the submodels. We also consider the qualitative dynamics of the full model.
Sensitivity analysis is done to determine the impact of some chosen parameters on the dynamics of malaria. Finally, numerical
simulations illustrate the potential impact of the treatment scenarios and confirm our analytical results
Description
Research Paper
Keywords
Citation
BioMed Research International Volume 2015, Article ID 659651, 14 pages http://dx.doi.org/10.1155/2015/659651