“New antitrypanosomal tetranortriterpenoids from Azadirachta indica”

Simple item page
dc.contributor.advisorGithua, M.
dc.contributor.advisorKeriko, J.
dc.contributor.advisorMurilla, G.
dc.contributor.advisorNdungu, M.
dc.contributor.advisorNyagah, G.
dc.contributor.authorHassanali, Ahmed
dc.date.accessioned2012-04-25T13:22:43Z
dc.date.available2012-04-25T13:22:43Z
dc.date.issued2012-04-25
dc.description.abstractOrganic extracts of the leaves of Azadirachta indica A. Juss. yielded ten antitrypanosomal terpenoids. Three of these (1 – 3), are novel and are derivatives of nimbolide and nimbin. They were extracted from chloroform fraction of methanol extract. These compounds were found to exhibit strong antitrypanosomal activities against Trypanosoma brucei rhodesiense with MIC values ranging of 6.9, 15.6 and 7.8 μg/ml respectively and were more active than Cymerlarsan ( a standard drug), which had an MIC value of 187.5 μg/ml when tested against T. b. rhodesiense The structures were elucidated by spectroscopic methods including; NMR, MS, UV and IR.
dc.description.sponsorshipKenyatta Universityen_US
dc.description.urihttp://www.ajol.info/index.php/ajtcam/article/view/54776/43266
dc.identifier.citationAfrican Journal of Traditional, Complementary and Alternative Medicines, Vol 7, No 3 (2010)
dc.identifier.issn0189-6016
dc.identifier.urihttp://ir-library.ku.ac.ke/handle/123456789/4312
dc.language.isoenen_US
dc.title“New antitrypanosomal tetranortriterpenoids from Azadirachta indica”en_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
New antitrypanosomal tetranotriterpenoids......pdf
Size:
59.01 KB
Format:
Adobe Portable Document Format
Description:
abstract
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
2.68 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
RP-Department of Chemistry