Pentacyclic triterpenoids from Embelia schimperi.
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Date
2003
Authors
Machocho, Alex K.
Kiprono, P.C.
Grinberg, S.
Bittner, S.
Journal Title
Journal ISSN
Volume Title
Publisher
Phytochemistry
Abstract
Five oleanane-type pentacyclic triterpenoids were isolated by chromatographic separation of a chloroform extract of the stem bark of Embelia schimperi. Three of these compounds have a methyleneoxy bridge. Two compounds, embelinone and schimperinone, are reported here for the first time from a natural source (they have been synthesized previously during chemical transformations). Their structures were determined by spectroscopic techniques, among which 2-D NMR was useful for complete characterization. Three of the triterpenoids exhibited mild antibacterial properties against the gram-positive bacterial strain Rhodococcus sp.
Description
Keywords
Embelia schimperi, Myrsinaceae, Pentacyclic triterpenoids, Embelinone, Schimperinone, Aegicerin, Protoprimulagenin A, Primulagenin A, Antibacterial activity
Citation
Phytochemistry 62 (4), 573-577.