Neutralizing antibody responses in Africa green monkeys naturally infected with simian immunodeficiency virus (SIVagm)

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dc.contributor.authorGicheru, M. M.
dc.contributor.authorOtsyula, M.
dc.contributor.authorSpearman, P.
dc.contributor.authorGraham, B.S.
dc.contributor.authorMiller, C.
dc.contributor.authorRobinson, H.L.
dc.contributor.authorHaigwood, N.L.
dc.contributor.authorMontefiori, D.C.
dc.date.accessioned2014-09-15T08:59:35Z
dc.date.available2014-09-15T08:59:35Z
dc.date.issued2014-09-15
dc.descriptionResearch Paperen_US
dc.description.abstractThis study assessed the magnitude and cross-reactivity of the neutralizing antibody response generated by natural SIV infection in wild-caught African green monkeys. Neutralizing antibodies of variable potency, sometimes exceeding a titer of 1:1,000, were detected in 20 of 20 SIV-seropositive African green monkeys in Kenya. Detection of those neutralizing antibodies was dependent on the strain of virus and the cells used for assay, where the most sensitive detection was made with SIVagm1532 in Sup T1 cells. Potent neutralization of SIVagm1532 was seen with contemporaneous autologous serum. Potent neutralization was also detected with laboratory-passaged SIVmac25 1 and SIVsmB670, but not with SIVsmE660 and two additional strains of SIVagm. Serum samples from rhesus macaques (Macaca mulatta) experimentally infected with either SIVmac25 1 or SIVsmE660 were capable of low-level neutralization of SIVagm. These results indicate that natural infection with SIV can generate strain-specific neutralizing antibodies in African green monkeys. They also indicate that some neutralization determinants of SIVagm are partially shared with SIV strains that arose in sooty mangabys and were subsequently transmitted to 1 rhesus macaques.en_US
dc.identifier.citationJournal of Medical Primatology 1999: 28: 97-104
dc.identifier.urihttp://ir-library.ku.ac.ke/handle/123456789/11239
dc.language.isoenen_US
dc.publisherJournal of Medical Primatology
dc.subjectantibodies - neutralizationen_US
dc.subjectnonhuman primatesen_US
dc.titleNeutralizing antibody responses in Africa green monkeys naturally infected with simian immunodeficiency virus (SIVagm)en_US
dc.typeThesisen_US
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