Arm-in-cage testing of natural human-derived mosquito repellents

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dc.contributor.authorJames, Logan G.
dc.contributor.authorNina, Stanczyk M.
dc.contributor.authorHassanali, Ahmed
dc.contributor.authorKemei, Joshua
dc.contributor.authorSantana, Antônio E.G.
dc.contributor.authorKarlos, Ribeiro A.L.
dc.contributor.authorJohn, Pickett A.
dc.contributor.authorMordue, Jennifer A.
dc.date.accessioned2012-10-19T11:30:58Z
dc.date.available2012-10-19T11:30:58Z
dc.date.issued2010
dc.description.abstractBackground: Individual human subjects are differentially attractive to mosquitoes and other biting insects. Previous investigations have demonstrated that this can be attributed partly to enhanced production of natural repellent chemicals by those individuals that attract few mosquitoes in the laboratory. The most important compounds in this respect include three aldehydes, octanal, nonanal and decanal, and two ketones, 6-methyl-5- hepten-2-one and geranylacetone [(E)-6,10-dimethylundeca-5,9-dien-2-one]. In olfactometer trials, these compounds interfered with attraction of mosquitoes to a host and consequently show promise as novel mosquito repellents. Methods: To test whether these chemicals could provide protection against mosquitoes, laboratory repellency trials were carried out to test the chemicals individually at different concentrations and in different mixtures and ratios with three major disease vectors: Anopheles gambiae, Culex quinquefasciatus and Aedes aegypti. Results: Up to 100% repellency was achieved depending on the type of repellent compound tested, the concentration and the relative composition of the mixture. The greatest effect was observed by mixing together two compounds, 6-methyl-5-hepten-2-one and geranylacetone in a 1:1 ratio. This mixture exceeded the repellency of DEET when presented at low concentrations. The repellent effect of this mixture was maintained over several hours. Altering the ratio of these compounds significantly affected the behavioural response of the mosquitoes, providing evidence for the ability of mosquitoes to detect and respond to specific mixtures and ratios of natural repellent compounds that are associated with host location. Conclusion: The optimum mixture of 6-methyl-5-hepten-2-one and geranylacetone was a 1:1 ratio and this provided the most effective protection against all species of mosquito tested. With further improvements in formulation, selected blends of these compounds have the potential to be exploited and developed as humanderived novel repellents for personal protection.en_US
dc.identifier.citationMalaria Journal 2010, 9:239en_US
dc.identifier.urihttp://ir-library.ku.ac.ke/handle/123456789/5768
dc.language.isoenen_US
dc.publisherBiomed Centralen_US
dc.titleArm-in-cage testing of natural human-derived mosquito repellentsen_US
dc.typeArticleen_US
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