Protective roles of free avian respiratory macrophages in captive birds
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Date
2016
Authors
Mbuvi, Mutua P.
Muya, Shadrack
Gicheru, Muita M.
Journal Title
Journal ISSN
Volume Title
Publisher
BioMed Central
Abstract
In the mammalian lung, respiratory macrophages provide front line defense against invading pathogens and particulate
matter. In birds, respiratory macrophages are known as free avian respiratory macrophages (FARM) and a dearth
of the cells in the avian lung has been purported to foreordain a weak first line of pulmonary defense, a condition
associated with high mortality of domestic birds occasioned by respiratory inflictions. Avian pulmonary mechanisms
including a three tiered aerodynamic filtration system, tight epithelial junctions and an efficient mucociliary escalator
system have been known to supplement FARM protective roles. Current studies, however, report FARM to exhibit
an exceptionally efficient phagocytic capacity and are effective in elimination of invading pathogens. In this review,
we also report on effects of selective synthetic peroxisome proliferator activated receptor gamma (PPAR γ) agonists
on non phlogistic phagocytic properties in the FARM. To develop effective therapeutic interventions targeting FARM
in treatment and management of respiratory disease conditions in the poultry, further studies are required to fully
understand the role of FARM in innate and adaptive immune responses.
Keywords: Avian lung, FARM, Phagocytosis, PPAR γ ligands
Description
DOI 10.1186/s40659-016-0090-7
Keywords
Avian lung, FARM, Phagocytosis, PPAR γ ligands
Citation
Biol Res (2016) 49:29, DOI 10.1186/s40659-016-0090-7