Antileishmanial activity of Aloe Secundiflora plant extracts against Leishmania Major (2013).

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dc.contributor.authorOgeto, T.K.
dc.contributor.authorOdhiambo, R.A.
dc.contributor.authorShivairo, R.S.
dc.contributor.authorMuleke, C.I.
dc.contributor.authorOsero, B.O.
dc.contributor.authorAnjili, C.
dc.contributor.authorIngonga, J.M.
dc.contributor.authorOsuga, I.M.
dc.date.accessioned2015-12-14T08:59:36Z
dc.date.available2015-12-14T08:59:36Z
dc.date.issued2013
dc.descriptionResearch Articleen_US
dc.description.abstractHuman leishmaniases are a spectrum of diseases caused by protozoan parasites of the genus Leishmania. In this study antileishmanial activity of the methanolic and water leaf extracts from Aloe secundiflora plant were analysed by determining the minimum inhibition concentration (MIC), nitric oxide (NO) production stimulation, infection rates (IR) and multiplication index (MI). Cytotoxicity of these plant extracts was also assessed. The MIC levels of water and methanolic plant extracts, amphotericin B and pentostam were 2000 μg/ml, 1000 μg/ml, 125μg/ml and 250 μg/ml respectively against Leishamnia major promastigotes. This study revealed that water and methanolic plant extracts significantly inhibited the growth of Leishmania parasites (P ≤ 0.05) as compared to amphotericin B with respect to the parasite infection rates and MIC levels. The IC50 for the water and methanolic plant extracts was 279.488 μg/ml and 42.824 μg/ml respectively. The elevated inhibitory activity observed in this study against Leishmania major parasites provides evidence and basis for their potential use as therapeutic agents against leishmaniasis.en_US
dc.identifier.citationAdvances in Life Science and Technology Vol.13, 2013en_US
dc.identifier.issn2224-7181
dc.identifier.issn2225-062X
dc.identifier.urihttp://ir-library.ku.ac.ke/handle/123456789/13981
dc.language.isoenen_US
dc.publisherIISTEen_US
dc.subjectAloe secundifloraen_US
dc.subjectPlant extractsen_US
dc.subjectLeishmania majoren_US
dc.subjectMinimum Inhibition Concentrations (MIC)en_US
dc.titleAntileishmanial activity of Aloe Secundiflora plant extracts against Leishmania Major (2013).en_US
dc.typeArticleen_US
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