Single-dose pharmacokinetics of anti-malarial chlorproguanil and its active metabolite chlorcycloguanil in healthy adult volunteers

Simple item page
dc.contributor.authorMberu, Edward G.
dc.date.accessioned2012-05-25T12:39:05Z
dc.date.available2012-05-25T12:39:05Z
dc.date.issued2012-05-25
dc.descriptionThe QR 201.M3 M32en_US
dc.description.abstractMalaria, often referred to as "the King of Diseases", is the single largest cause of disease and death every year in tropical countries. It is possible to prevent malaria infections if those concerned (travelers to, and residents of, endemic areas) are well informed about the dangers of contracting the disease if they do not take preventative measures. The main preventative measure is through prophylaxis (drug taking) which should be used for as long as there is no effective and sure immunising vaccine. While malaria remains a major, worldwide, public health problem and resistance to currently available drugs becomes more prevalent, interest had focused on the understanding of the pharmacokinetic characteristics of available anti-malarial. These are parameters, which govern the time-course of the movement of drugs into, around and out of the body. Previously, many of these drugs had been little studied, and it is now anticipated that increasing information on the disposition of drugs, both current and under development, may improve their rational use and enhance their role as possible tools to combat malaria. In this study, the rate of elimination of both CPG and CCG from the body (circulation) have been shown to be similar to that of proguanil (an analogue of CPG) which is taken daily, and its active metabolite, cycloguanil. This finding has supported the hypothesis that the current recommended weekly dose of CPG hydrochloride (20mg) is inappropriate. Inter-subject variation was found in the extent of metabolism of CPG to CCG, although the magnitude of this variation was found to be less than that reported for proguanil. These results are of general importance in the search for effective chemoprophylactic drugs, and of specific importance in terms of the relationship between efficacy and dosage of CPG hydrochloride as a chemoprophylactic drug.en_US
dc.description.sponsorshipKenyatta Universityen_US
dc.identifier.urihttp://ir-library.ku.ac.ke/handle/123456789/4778
dc.language.isoenen_US
dc.subjectMalariaen_US
dc.titleSingle-dose pharmacokinetics of anti-malarial chlorproguanil and its active metabolite chlorcycloguanil in healthy adult volunteersen_US
dc.typeThesisen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Single-dose pharmacokinetics of the anti-malarial......pdf
Size:
38.12 MB
Format:
Adobe Portable Document Format
Description:
Full Text Thesis
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
2.68 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
MST-Department of Public Health