Seroprevalence of measles IgG among HIV-1-infected and uninfected Kenyan adults.

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dc.contributor.authorGataguta, A.
dc.contributor.authorMerkel, M.
dc.contributor.authorYoussef, L. B.
dc.contributor.authorNewman, L.P.
dc.contributor.authorGitome, V.
dc.contributor.authorGataguta, A.
dc.contributor.authorLohman, P.B.
dc.contributor.authorBosire, R.
dc.contributor.authorFarquhar, C.
dc.date.accessioned2014-05-28T12:45:38Z
dc.date.available2014-05-28T12:45:38Z
dc.date.issued2014-02
dc.descriptiondoi: 10.1016/j.ijid.2013.10.018. Epub 2013 Dec 11en_US
dc.description.abstractDespite global efforts to reduce measles incidence, outbreaks continue to occur in developing countries where HIV-1-infected adults represent a vulnerable population. Immunization campaigns have targeted children, although little is known about the levels of measles protection in adult populations in Kenya. The objective of this study was to determine seroprevalence and titers of measles IgG among HIV-1-infected and uninfected adults in Nairobi, Kenya. The presence of anti-measles IgG was measured in cryopreserved serum of 257 HIV-1-infected and 367 uninfected adults using a commercial ELISA (Enzygnost, Germany). The measles IgG concentration was calculated for those samples that were positive. Overall, 96% of adults were measles seropositive and the mean measles IgG concentration among those who were seropositive was 4134 mIU/ml, which is well above previously reported protective levels. There was no statistical difference in seroprevalence or antibody concentration between the HIV-infected and HIV-uninfected groups. While local vaccination efforts and circulating measles infection likely contribute to this high measles seroprevalence rate, these data are unique to an urban population and may not reflect a country-wide distribution. Our results suggest that reduced immunity among HIV-1-infected adults is not a major contributor to measles resurgence in Kenya.en_US
dc.identifier.citationInt J Infect Dis. 2014 Feb;19:103-5en_US
dc.identifier.issn1201-9712
dc.identifier.urihttp://ir-library.ku.ac.ke/handle/123456789/9679
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectAdult immunityen_US
dc.subjectHIVen_US
dc.subjectIgG antibodyen_US
dc.subjectKenyaen_US
dc.subjectMeaslesen_US
dc.subjectSub-Saharan Africaen_US
dc.titleSeroprevalence of measles IgG among HIV-1-infected and uninfected Kenyan adults.en_US
dc.typeArticleen_US
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