Roles of DDX5 in the tumorigenesis, proliferation, differentiation, metastasis and pathway regulation of human malignancies

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dc.contributor.authorNyamao, Rose Magoma
dc.contributor.authorWu, Jing
dc.contributor.authorYu, Li
dc.contributor.authorXiao, Xiao
dc.contributor.authorZhang, Feng-Min
dc.date.accessioned2019-12-10T09:31:45Z
dc.date.available2019-12-10T09:31:45Z
dc.date.issued2019
dc.descriptionResearch Articleen_US
dc.description.abstractThe DEAD-box RNA helicase DDX5 is a member of a family of highly conserved proteins involved in gene-expression regulation and ATP-dependent RNA helicase activities. Recently, it has been reported to be aberrantly expressed in many tumors, and is linked to the regulation of many cancer-related pathways. It co-activates many transcription factors, with profound implications for cancer development, and the de-regulation of its functions is ultimately associated with tumor formation and progression. Moreover, it is strongly implicated in the tumorigenesis, invasiveness and metastasis, as well as the proliferation of several cancer types. In this review, we seek to elucidate the role of DDX5 in the development and progression of human malignancies and put forward its prospective applications in future cancer research.en_US
dc.identifier.citationBiochimica et Biophysica Acta (BBA) - Reviews on Cancer Volume 1871, Issue 1, January 2019, Pages 85-98en_US
dc.identifier.urihttps://www.sciencedirect.com/science/article/abs/pii/S0304419X18301380?via%3Dihub
dc.identifier.urihttp://ir-library.ku.ac.ke/handle/123456789/20038
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectDDX5en_US
dc.subjectTumorigenesisen_US
dc.subjectHuman malignanciesen_US
dc.subjectApoptosisen_US
dc.titleRoles of DDX5 in the tumorigenesis, proliferation, differentiation, metastasis and pathway regulation of human malignanciesen_US
dc.typeArticleen_US
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