Cellular Immune Response and Abomasum worm burden in Goats Vaccinated with HC58cDNA Vaccine against H. contortus Infection
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Date
2013
Authors
Osuga, Isaac M.
Muleke, C. I.
Yan, Ruofeng
Sun, Yanming
Osuga, I.M.
Shivairo, R.S.
Li, Xiangrui
Journal Title
Journal ISSN
Volume Title
Publisher
www.iiste.org
Abstract
Abstract Vaccination with DNA vaccines derived from adult H. contortus induces significant
level of protection against homologous infection in goat. To date however, mechanism of
protection is not well understood, especially in goat. In this study, HC58 DNA vaccinated
goats were artificially infected with 5, 000 dose of infective H. contortus L 3 (third larval
stage), and cellular immune responses and abomasum worm burden examined. The results
showed that peripheral CD4+, CD8+ T and B lymphocytes for nematode challenged
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Citation
Advances in Life Science and Technology, 13, 26-33 2013