Association of Differential Symptoms of Stress to Hair Cortisol and Cortisone Concentrations among Pregnant Women in Kenya

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dc.contributor.authorMusana, Joseph W
dc.contributor.authorCohen, Craig R
dc.contributor.authorKuppermann, Miriam
dc.contributor.authorGerona, Roy
dc.contributor.authorWanyoro, Anthony
dc.contributor.authorAguilar, David
dc.contributor.authorSantos, Nicole
dc.contributor.authorTemmerman, Marleen
dc.contributor.authorWeiss, Sandra J
dc.date.accessioned2023-07-11T13:17:49Z
dc.date.available2023-07-11T13:17:49Z
dc.date.issued2020
dc.descriptionArticleen_US
dc.description.abstractObjectives: The purpose of this study was to characterize the stress experienced by pregnant women in Kenya and assess the relationship between perceived stress and stress-related biomarkers of cortisol and cortisone. Background: Kenyan women are exposed to multiple stressors that may result in chronic stress. However, antenatal stress has not been examined and characterized in Kenya; nor has the relationship between pregnant women’s self-reported stress and stress biomarkers been established. Methods: One hundred and fifty women were recruited between 22 and 28 weeks gestation. Participants completed the Perceived Stress Scale (PSS) and a sociodemographic questionnaire. Hair samples were obtained for analysis of cortisol and cortisone. Factor analysis was used to extract unique clusters of stress symptoms from items in the PSS. Regression models were computed to examine relationships of stress to cortisone and cortisol, controlling for obstetric risk. Results: Mean age of the women was 25 years (SD ¼ 5, ±16–41). Their degree of perceived stress and cortisol/cortisone concentrations both indicated moderate levels of stress. There was no association between general perceived stress and either hair cortisol or cortisone. However, factor analysis of the PSS identified three clusters of stress symptoms and one cluster - a woman’s negative frame of mind regarding life and inefficacy in handling its problems - was associated with higher levels of cortisone (b¼ .231, p ¼ 0.011). Conclusions: Specific stress symptoms may have unique relationships to specific biomarkers and be more useful in assessment than general perceived stress. Assays of both hair cortisol and cortisone might enable a more comprehensive assessment of glucocorticoid activity and better prediction of health risks from stress.en_US
dc.identifier.citationMusana, J. W., Cohen, C. R., Kuppermann, M., Gerona, R., Wanyoro, A., Aguilar, D., ... & Weiss, S. J. (2020). Association of differential symptoms of stress to hair cortisol and cortisone concentrations among pregnant women in Kenya. Stress, 23(5), 556-566.en_US
dc.identifier.otherhttps://doi.org/10.1080/10253890.2019.1696305
dc.identifier.urihttp://ir-library.ku.ac.ke/handle/123456789/26158
dc.language.isoenen_US
dc.publisherTaylor \& Francisen_US
dc.subjectMotheren_US
dc.subjectpregnancyen_US
dc.subjectperceived stressen_US
dc.subjecthairen_US
dc.subjectcortisolen_US
dc.subjectcortisoneen_US
dc.titleAssociation of Differential Symptoms of Stress to Hair Cortisol and Cortisone Concentrations among Pregnant Women in Kenyaen_US
dc.typeArticleen_US
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