Microsatellite Typing Reveals Strong Genetic Structure of Schistosoma Mansoni from Localities in Kenya

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dc.contributor.authorMburu, D.N.
dc.contributor.authorAgola, L.E.
dc.contributor.authorDeJong, R.J.
dc.contributor.authorMungai, B.N.
dc.contributor.authorMuluvi, G. M.
dc.contributor.authorNjagi, E.N.M.
dc.contributor.authorLoker, E.S.
dc.contributor.authorMkoji, G.M.
dc.date.accessioned2014-07-22T09:49:58Z
dc.date.available2014-07-22T09:49:58Z
dc.date.issued2006-11-30
dc.descriptionDOI: 10.1016/j.meegid.2006.03.002en_US
dc.description.abstractGenetic diversity and population structure of seven populations of Schistosoma mansoni sampled in Kenya were assessed using five microsatellite markers. The mean number of alleles per locus, expected heterozygosity in Hardy–Weinberg equilibrium and pairwise FST values ranged from 5.2 to 10.7, 0.5–0.8 and 3.6–27.3%, respectively. These data reveal that S. mansoni populations in Kenyan have relatively high levels of genetic diversity and is significantly differentiated. Our data combined with information on biogeography support the hypothesis that the strong genetic structure in Kenyan schistosomes is as a result of limited gene flow and large population sizes. Resistance to anthelminthics has not been reported among the Kenyan schistosomes, we hypothesize that this is probably due to the very little gene flow among populations, thereby limiting opportunities for the spread of rare alleles that might confer resistance to the drugs.en_US
dc.identifier.citationInfection, Genetics and Evolution Volume 6, Issue 6, November 2006, Pages 484–490en_US
dc.identifier.urihttp://ir-library.ku.ac.ke/handle/123456789/10545
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectSchistosoma mansoni,en_US
dc.subjectMicrosatellite,en_US
dc.subjectGenetic diversity,en_US
dc.subjectPopulation structure,en_US
dc.subjectSchistosomiasis,en_US
dc.subjectKenya.en_US
dc.titleMicrosatellite Typing Reveals Strong Genetic Structure of Schistosoma Mansoni from Localities in Kenyaen_US
dc.typeArticleen_US
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