Antifangal Activity of Tabernaemontana stapfiana Britten (Apocynaceae) Organic Extracts

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dc.contributor.authorMachocho, Alex K.
dc.contributor.authorRuttoh, E.K.
dc.contributor.authorBii, C.C
dc.contributor.authorTarus, Paul K.
dc.contributor.authorKarimi, L.K.
dc.contributor.authorOkemo, P. O.
dc.date.accessioned2013-10-09T15:39:50Z
dc.date.available2013-10-09T15:39:50Z
dc.date.issued2009
dc.description.abstractThe methanol and successive (hexane, dichlroromethane, ethyl acetate and methanol) extracts of leaves, fruits, root and stem barks of Tabernaemontana stapfiana Britten were investigated for antifungal activity against four fungi; Candida albicans, Cryptococcus neoformans, Microsporum gypseum and Trichophyton mentagrophytes. The extracts of the different plant parts showed varied activities against the tested fungi with the stem and root barks showing significant antifungal activities. The minimum inhibitory concentrations (MICs) of methanol and sequential extracts ranged between 31.25 and 8000 μg/ml while the minimum fungicidal concentrations (MFCs) ranged between 125 and 8000 μg/ml. Among the test microorganisms, Candida albicans was the most susceptible with the lowest MIC of 31.25 μg/ml followed by Cryptococcus neoformans with an MIC of 62.25 μg/ml. These results show that it is possible to find antifungal compounds in the extracts of T. stapfiana.en_US
dc.identifier.citationPharmacognosy Research 1 (6): 387-391.en_US
dc.identifier.urihttp://ir-library.ku.ac.ke/handle/123456789/7444
dc.language.isoenen_US
dc.publisherPharmacognosy Researchen_US
dc.subjectTabernaemontana stapfiana Brittenen_US
dc.subjectApocynaceaeen_US
dc.subjectAntifungal activityen_US
dc.subjectMinimum inhibitory concentrationen_US
dc.subjectMinimum fungicidal concentrationen_US
dc.titleAntifangal Activity of Tabernaemontana stapfiana Britten (Apocynaceae) Organic Extractsen_US
dc.typeArticleen_US
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