Human Papillomavirus Types Associated with Cervical Dysplasia among HIV- and Non-HIV-Infected Women Attending Reproductive Health Clinics in Eastern Kenya
Loading...
Date
2021
Authors
Njue, James Kinoti
Muturi, Margaret
Kamau, Lucy
Lwembe, Raphael
Journal Title
Journal ISSN
Volume Title
Publisher
Hindawi
Abstract
Background. Human papillomavirus (HPV) causes over 99% of all cervical cancer globally. In 2019, it was responsible for 3286
deaths in Kenya. Data on the epidemiological distribution of HPV genotypes by cervical dysplasia and HIV-infected women
which is important in designing prevention strategy monitoring treatment and management of cervical cancer is lacking in
Eastern Kenya. Objective. To determine HPV genotype prevalence and their association with cervical dysplasia among HIVinfected
(cases) and noninfected (control) women aged 18-48 years seeking reproductive healthcare. Methods. A cervical
broom was softly rotated 360 degrees five times to exfoliate cells from the region of the transformation zone, squamocolumnar
junction, and endocervical canal for HPV genotyping. Social-demographic and risk factors responsible for HPV acquisition
were collected using a questionnaire. Laboratory outcome and questionnaire data statistical relationships were computed using
Pearson chi-square test. Results. 317 women (cases: 161 (50.8%), control 156 (49.2%), mean age: 34.3,SD ± 10:4, range 18-46
years) were recruited from Embu (85/317 (26.8%)), Isiolo (64/317 (20.2%)), Kirinyaga (56/317 (17.7%)), Meru (81/317
(25.6%)), and Tharaka-Nithi (31/317 (9.8%)). The frequency HPV genotypes detected by cervical dysplasia were CIN1 (cases:
HPV81 (12/317 (3.8%)), HPV11 (2/317 (0.6%)); control: HPV53 and 66 coinfection (1/317 (0.3%)), CIN2 (cases: HPV11,
HPV16, HPV66 ((1/317 (0.3%) each), HPV81 (6/317 (1.9%)), and single case (1/317 (0.3%)) of HPV11 and 66, HPV81 and
44, HPV81 and 88, HPV9 and 53, and HPV16 and 58 coinfection; control: HPV81 (2/317 (0.6%)) and invasive cervical cancer
(cases: HPV16 (1/317 (0.3%)) and HPV81 (3/317 (0.9%)); control: HPV16 and 66 (1/317 (0.3%))).Conclusions. There was a
higher frequency of both high-risk and low-risk HPV genotypes associated with cervical dysplasia among HIV-infected than
HIV-uninfected women seeking reproductive health care. This study provides epidemiological data on the existence of
nonvaccine HPV types associated with cervical dysplasia in the region.
Description
article
Keywords
Citation
Njue, J. K., Muturi, M., Kamau, L., & Lwembe, R. (2021). Human papillomavirus types associated with cervical dysplasia among HIV-and non-HIV-infected women attending reproductive health clinics in eastern Kenya. BioMed Research International, 2021.