Uropathogens Antibiotic Resistance Patterns Among Type 2 Diabetic Patients in Kisii Teaching and Referral Hospital, Kenya
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Date
2018
Authors
Mageto, Vincent Mogaka
Gatwiri, Mathenge Scholastica
Njoroge, Wachuka
Journal Title
Journal ISSN
Volume Title
Publisher
Pan African Medical Journal
Abstract
Introduction: Non-insulin dependent diabetes mellitus is a major risk factor for urinary tract infections. Irrational use of antibiotics has led to the
emergency of uropathogens resistant to available antibiotics. The main objective was to determine the bacterial causative agents of urinary tract
infections and their antibiotic resistance patterns. Methods: One hundred and eighty (180) type 2 diabetic patients were recruited to take part in
the study. Urine samples were collected and cultured for urinary tract infections diagnosis and antibiotic sensitivity. Results: A total of 35 isolates
were obtained from the study. All the isolates were sensitive to gentamicin. All 21 (100%) isolates of E. coli were sensitive to gentamicin and
cephalexin. All 10 (100%) K. pneumoniaeisolates were sensitive to gentamicin and nitrofurantoin. Out of the 21 E. coli isolates, five of them
showed resistance to ampicillin, three E. coli isolates showed resistance to nitrofurantoin and another three E. coliisolates showed resistance to cotrimoxazole.
Out of 10 K. pneumoniae isolates, two of them were found to be resistant to ampicillin, one K. pneumoniae isolate was resistant to
cephalexin and two K. pneumoniaeisolates were resistant to co-trimoxazole. Out of the four P. mirabilis isolates, there were three cases where one
isolate was each resistant to ampicillin, nitrofurantoin and co-trimoxazole. Conclusion: There is a need to have a regular screening of bacterial
isolates causing urinary tract infection in diabetic patients and their antibiotic sensitivity in order to have effective therapy. Present findings show
that there is increased resistance to the commonly prescribed antibiotics
Description
Article
Keywords
Type 2 diabetes mellitus, urinary tract infections, antibiotic sensitivity, E. coli, K. pneumoniae
Citation
Mageto, V. M., Gatwiri, M. S., & Njoroge, W. (2018). Uropathogens antibiotic resistance patterns among type 2 diabetic patients in Kisii Teaching and Referral Hospital, Kenya. The Pan African Medical Journal, 30.