Polymorphic Variability in the Interleukin (IL)-1Beta Promoter Conditions Susceptibility to Severe Malarial Anemia and Functional Changes in IL-1Beta Production

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dc.contributor.authorOtieno, Micheal Frederick
dc.contributor.authorOuma, C.
dc.contributor.authorDavenport, G. C.
dc.contributor.authorAwandare, G. A.
dc.contributor.authorKeller, C. C.
dc.contributor.authorWere, T.
dc.contributor.authorVulule, J. M.
dc.contributor.authorMartinson, J.
dc.contributor.authorOng'echa, J. M.
dc.contributor.authorFerrell, R. E.
dc.contributor.authorPerkins, D. J.
dc.date.accessioned2014-01-20T08:49:59Z
dc.date.available2014-01-20T08:49:59Z
dc.date.issued2008-10
dc.descriptiondoi: 10.1086/592055.en_US
dc.description.abstractInterleukin (IL)-1beta is a cytokine released as part of the innate immune response to Plasmodium falciparum. Because the role played by IL-1beta polymorphic variability in conditioning the immunopathogenesis of severe malarial anemia (SMA) remains undefined, relationships between IL-1beta promoter variants (-31C/T and -511A/G), SMA (hemoglobin [Hb] level <6.0 g/dL), and circulating IL-1beta levels were investigated in children with parasitemia (n= 566) from western Kenya. The IL-1beta promoter haplotype -31C/-511A (CA) was associated with increased risk of SMA (Hb level <6.0 g/dL; odds ratio [OR], 1.98 [95% confidence interval {CI}, 1.55-2.27]; P < .05) and reduced circulating IL-1beta levels (p <.05). The TA (-31T/-511A) haplotype was nonsignificantly associated with protection against SMA (OR, 0.52 [95% CI, 0.18-1.16]; p =.11) and elevated IL-1beta production ( p<.05). Compared with the non-SMA group, children with SMA had significantly lower IL-1beta levels and nonsignificant elevations in both IL-1 receptor antagonist (IL-1Ra) and the ratio of IL-1Ra to IL-1beta. The results presented demonstrate that variation in IL-1beta promoter conditions susceptibility to SMA and functional changes in circulating IL-1beta levels.en_US
dc.identifier.urihttp://ir-library.ku.ac.ke/handle/123456789/8707
dc.language.isoenen_US
dc.publisherPubMeden_US
dc.titlePolymorphic Variability in the Interleukin (IL)-1Beta Promoter Conditions Susceptibility to Severe Malarial Anemia and Functional Changes in IL-1Beta Productionen_US
dc.typeArticleen_US
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