In Vitro and in Vivo Antileishmanial Efficacy of a Combination Therapy of Diminazene and Artesunate against Leishmania Donovani in BALB/c Mice.

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dc.contributor.authorGicheru, M. M.
dc.contributor.authorMutiso, J. M.
dc.contributor.authorMacharia, J. C.
dc.contributor.authorBarasa, M.
dc.contributor.authorTaracha, E.
dc.contributor.authorBourdichon, A. J.
dc.date.accessioned2014-01-16T07:29:29Z
dc.date.available2014-01-16T07:29:29Z
dc.date.issued2011
dc.description.abstractThe in vitro and in vivo activity of diminazene (Dim), artesunate (Art) and combination of Dim and Art (Dim-Art) against Leishmania donovani was compared to reference drug; amphotericin B. IC50 of Dim-Art was found to be 2.28 ± 0.24 µg/mL while those of Dim and Art were 9.16 ± 0.3 µg/mL and 4.64 ± 0.48 µg/mL respectively. The IC50 for Amphot B was 0.16 ± 0.32 µg/mL against stationary-phase promastigotes. In vivo evaluation in the L. donovani BALB/c mice model indicated that treatments with the combined drug therapy at doses of 12.5 mg/kg for 28 consecutive days significantly (p < 0.001) reduced parasite burden in the spleen as compared to the single drug treatments given at the same dosages. Although parasite burden was slightly lower (p < 0.05) in the Amphot B group than in the Dim-Art treatment group, the present study demonstrates the positive advantage and the potential use of the combined therapy of Dim-Art over the constituent drugs, Dim or Art when used alone. Further evaluation is recommended to determine the most efficacious combination ratio of the two compounds.en_US
dc.identifier.urihttp://ir-library.ku.ac.ke/handle/123456789/8593
dc.language.isoenen_US
dc.publisherPubMeden_US
dc.titleIn Vitro and in Vivo Antileishmanial Efficacy of a Combination Therapy of Diminazene and Artesunate against Leishmania Donovani in BALB/c Mice.en_US
dc.typeArticleen_US
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