The Potential for Use of Haematological and Anti-Ige Humoral Responses as Phenotypic Markers for Tick Resistance in Cattle

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dc.contributor.authorNgetich, Collins
dc.contributor.authorKamau, Lucy
dc.contributor.authorSimbauni, Jemimah
dc.contributor.authorMwendia, Charles
dc.contributor.authorOwido, Milton
dc.contributor.authorKiio, Irene
dc.contributor.authorMatika, Oswald
dc.contributor.authorFoster, Sarah
dc.contributor.authorBirkett, Michael
dc.contributor.authorDjikeng, Appolinaire
dc.contributor.authorWatson, Kellie Anne
dc.contributor.authorGithaka, Naftaly
dc.date.accessioned2024-02-26T07:01:08Z
dc.date.available2024-02-26T07:01:08Z
dc.date.issued2023-11-23
dc.descriptionArticleen_US
dc.description.abstractApproximately 80% of the global cattle population is at risk of infestation and infection by ticks and tick-borne diseases (TTBDs). The economic losses from animal mortality, reduced production, vector control costs and animal treatment are very substantial, hence there is an urgent need to develop and deploy alternative vector control strategies. Breeding for host tick resistance has the potential for sustainable large-scale TTBD control especially in cattle. The gold standard method for phenotyping tick resistance in cattle is by counting ticks on the body but is very laborious and subjective. Better methods for phenotyping tick resistance more objectively, faster and at scale, are essential for selecting host genetic resistance to ticks. This study investigated the correlation between haematological cellular profiles and immunological responses (immunoglobulin E, IgE) and full body tick counts in herds of Bos indicus and Bos taurus following artificial tick challenge with Rhipicephalus decoloratus larvae. Fifty-four Friesian and Ayrshire (Bos taurus) and 52 East African Zebu (Bos indicus) calves were each infested with ~2500 larvae. Near-replete adult female ticks (≥ 4.5 mm) were counted daily from Day 20–25. Blood and serum samples were obtained from each animal on Days 0 and 23 for cellular blood and IgE titre analysis, respectively. The indicine cattle were refractory to R. decoloratus infestation in comparison with the taurine breed (P < 0.0001). Repeated measurements of blood components pre-infestation revealed a significant (P < 0.05) association with tick count in IgE and red blood cells, haematocrit, and haemoglobin post-infestation. There was also a strong positive correlation between the tick counts and red blood cell numbers, haemoglobin, haematocrit, and IgE concentration (P < 0.0001) following tick challenge. The application of this approach to phenotype host resistance needs to be assessed using higher cattle numbers and with different tick species or generaen_US
dc.identifier.citationNgetich, C., Kamau, L., Simbauni, J., Mwendia, C., Owido, M., Kiio, I., ... & Githaka, N. (2024). The potential for use of haematological and anti-IgE humoral responses as phenotypic markers for tick resistance in cattle. Current Research in Parasitology & Vector-Borne Diseases, 5, 100159.en_US
dc.identifier.urihttps://doi.org/10.1016/j.crpvbd.2023.100159
dc.identifier.urihttps://ir-library.ku.ac.ke/handle/123456789/27680
dc.language.isoenen_US
dc.publisherElsevier B.Ven_US
dc.subjectTicksen_US
dc.subjectCattleen_US
dc.subjectResistanceen_US
dc.subjectIgEen_US
dc.subjectPhenotypeen_US
dc.titleThe Potential for Use of Haematological and Anti-Ige Humoral Responses as Phenotypic Markers for Tick Resistance in Cattleen_US
dc.typeArticleen_US
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