Antibiotic resistance patterns of Escherichia coli isolated from HIV-sero positive adults at Mbagathi District Hospital, Nairobi, Kenya.

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dc.contributor.authorEmacar, Jacinta
dc.contributor.authorOkemo, P. O.
dc.contributor.authorGatheri, G.
dc.contributor.authorKariuki, S.
dc.date.accessioned2012-10-24T12:04:13Z
dc.date.available2012-10-24T12:04:13Z
dc.date.issued2010
dc.description.abstractObjectives: To determine changes in antibiotic resistance patterns in E. coli from persons living with HIV/AIDS (PLWHA). Methodology and results: A total of 264 strains of E. coli were isolated from PLWHA. The isolates were tested for antimicrobial susceptibility by Kirby Bauer disk diffusion technique. Out of the 216 (81.81%) E.coli from PLWHA and taking antibiotics (HIV+A+), 209-(96.76%), 198-(91.67%) and 188- (87.04%) isolates were resistant to trimethoprim-sulphamethazole, tetracycline and ampicillin respectively. All isolates from PLWHA not taking antibiotics(HIV+A-) were sensitive to fluoroquinolones and nalidixic acid but thirty nine (83.33%) of the them were resistant to trimethoprim-sulphamethazole.The most prevalent resistance was to trimethoprim-sulphamethazole and ampicillin. Conclusion and application of findings: prolonged exposure to antibiotic makes PLWHA harbour strains of E. coli that are significantly more resistant to antibiotics with varying resistance patterns. The findings of this study should have major implications on public health policy guidelines on managing antimicrobial resistance in PLWHA, antimicrobial resistance detection modules and intervention schemes. It can also help in planning regular monitoring of antibiotic resistance patterns in order to provide the basis for developing rational prescription guidelines. Key words: Acquired immunodeficiency syndrome, opportunistic infections, antibiotics, Escherichia coli, resistance
dc.description.sponsorshipObjectives: To determine changes in antibiotic resistance patterns in E. coli from persons living with HIV/AIDS (PLWHA). Methodology and results: A total of 264 strains of E. coli were isolated from PLWHA. The isolates were tested for antimicrobial susceptibility by Kirby Bauer disk diffusion technique. Out of the 216 (81.81%) E.coli from PLWHA and taking antibiotics (HIV+A+), 209-(96.76%), 198-(91.67%) and 188- (87.04%) isolates were resistant to trimethoprim-sulphamethazole, tetracycline and ampicillin respectively. All isolates from PLWHA not taking antibiotics(HIV+A-) were sensitive to fluoroquinolones and nalidixic acid but thirty nine (83.33%) of the them were resistant to trimethoprim-sulphamethazole.The most prevalent resistance was to trimethoprim-sulphamethazole and ampicillin. Conclusion and application of findings: prolonged exposure to antibiotic makes PLWHA harbour strains of E. coli that are significantly more resistant to antibiotics with varying resistance patterns. The findings of this study should have major implications on public health policy guidelines on managing antimicrobial resistance in PLWHA, antimicrobial resistance detection modules and intervention schemes. It can also help in planning regular monitoring of antibiotic resistance patterns in order to provide the basis for developing rational prescription guidelines.en_US
dc.identifier.citationJournal of Applied Biosciences 27: 1705 - 1714en_US
dc.identifier.issn1997–5902
dc.identifier.urihttp://ir-library.ku.ac.ke/handle/123456789/5815
dc.language.isoenen_US
dc.publisherBiosciences Journalsen_US
dc.subjectAcquired immunodeficiency syndromeen_US
dc.subjectopportunistic infectionsen_US
dc.subjectantibioticsen_US
dc.subjectEscherichia colien_US
dc.subjectresistanceen_US
dc.titleAntibiotic resistance patterns of Escherichia coli isolated from HIV-sero positive adults at Mbagathi District Hospital, Nairobi, Kenya.en_US
dc.typeArticleen_US
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