Repellent Activities of Stereoisomers of p-Menthane-3,8-diols Against Anopheles gambiae (Diptera: Culicidae)
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Date
2002
Authors
Hassanali, Ahmed
Barasa, S. S.
Ndiege, I. O.
Lwande, W.
Journal Title
Journal ISSN
Volume Title
Publisher
Entomological Society of America
Abstract
Four stereoisomers of p-menthane-3,8-diol, which make up the natural product obtained from Eucalyptus citriodora, were synthesized through stereoselective procedures. Repellency assays showed that all the four were equally active against Anopheles gambiae s.s. Racemic blends and the diastereoisomeric mixture of all the four isomers were also equally repellent. 1-α-terpeneol, with a single hydroxyl function at C-8 and unsaturation at C-8, and menthol, with a single hydroxyl function at C-3, were not repellent. The practical implication of these results is discussed.
Description
doi: http://dx.doi.org/10.1603/0022-2585-39.5.736
Keywords
Eucalyptus citriodora, p-menthane-3, 8-diol, stereoisomers, Anopheles gambiae s.s, repellency
Citation
Journal of Medical Entomology 39(5):736-741. 2002