Zanthoxoaporphines A–C: Three new larvicidal dibenzo[de,g]quinolin-7-one alkaloids from Zanthoxylum paracanthum (Rutaceae)

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Date
2013Author
Samita, Fidelis N.
Sandjo, L. P.
Ndiege, I. O.
Hassanali, Ahmed
Lwande, W.
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The bioassay-guided purification of Zanthoxylum paracanthum (Rutaceae) extracts led to the isolation of three new alkaloids,
namely 1-hydroxy-10-methoxy-7H-dibenzo[de,g]quinolin-7-one (zanthoxoaporphine A, 2), 1-hydroxy-7H-dibenzo[de,g]quinolin-
7-one (zanthoxoaporphine B, 3) and 1,8-dihydroxy-9-methoxy-7H-dibenzo[de,g]quinolin-7-one (zanthoxaporphine C, 4), and a
known lignan identified as sesamin (1). Isolation and purification of the constituent compounds was achieved through conventional
chromatographic methods. The chemical structures of the isolated compounds were determined on the basis of UV, IR, NMR and
MS data, and confirmed by comparison with those reported in the literature. The larvicidal activity of some of the isolated compounds
was investigated by using third-instar Anopheles gambiae larvae.